Cell Cycle
DNA Structure
Replication
Repair and Mutagenesis
Grab Bag
100
These are the key players in allowing a cell to progress through the stages of the cell cycle.
What are CDK's?
100
Deoxyribose differs from ribose in that it is deoxygenated at this carbon.
What is the 2-prime carbon?
100
Lagging strands are discontinuous because they need to wait for this action in order to be synthesized.
What is the further opening of the replication fork?
100
Oxidative deamination of Cytosine is likely to result in the formation of this nitrogenous base
What is Uracil?
100
This is DNA structure consisting of a B DNA and another single stranded DNA.
What is triple-helical DNA?
200
The restriction point, or point of no return, is found in this phase.
What is G1?
200
DNA polarity/directionality is expressed in terms of two "ends". This is the end where DNA polymerases are able to extend the strand.
What is the 3' end?
200
The binding of DNAa to the binding sites of DNA causes tensions in the strand. The DNA opens at this "open complex" consisting of 13-mers rich in these bases.
What are A and T?
200
This mutation results from the covalent bonding of two bases on the same strand.
What are pyrimidine dimers?
200
Linker connects to these rodlike proteins in the histone complexes.
What are H1 proteins?
300
pRB is phosphorylated and eventually drops this carried protein.
What is E2F?
300
This purine-pyrimidine pair is connected by three hydrogen bonds.
What are C and G?
300
This flaw in DNA polymerases is the reason why RNA primers are synthesized instead of DNA primers and is also the reason why DNA replication MUST be semiconservative.
What is their inability to synthesize new strands from scratch?
300
In order of a base to be repaired when polIII is too far ahead to initiate exonuclease activity, these enzymes must attach to the site and cleave the error.
What are repair endonucleases?
300
This enzyme cleaves segments of one DNA strand and passes them through the other strand to prevent supercoiling of DNA as helicase unwinds.
What is Topoisomerase?
400
Non-proliferating cells such as neurons or cells that have been ordered to halt their progress through the cell cycle are said to be stuck in this phase
What is G0?
400
The existence of these sites in DNA allows proteins and enzymes to recognize and bind to base pairs without having to break the sugar-phosphate backbone, especially in the context of DNAa
What is the major groove?
400
Telomerase synthesizes new DNA at the ends of chromosones from this template
What is an encoded RNA template?
400
This process allows repair endonucleases and excinucleases to recognize the daughter strand.
What is DNA methylation of the parent strand?
400
This is the eukaryotic equivalent of single-stranded biding proteins.
What is RPA?
500
These spindle fibers are found close to the centrioles and unattached to the centromeres of the chromatids.
What are astral microtubules?
500
This is the tautomeric form of Cytosine
What is C (imino)?
500
Tag (T-antigen) has this dual function in SV40 DNA-replication.
What are binding to the origin, and acting as the helicase?
500
What percentage of DNA is said to be non-coding?
What is 98%?
500
Concentration of cyclins sharply declines after this mitotic phase.
What is Metaphase?