Our Lord and Savior
The small east coast town based institution where our lord and savior completed her post-doctoral training
What is the Whitehead Institute?
In the immunotherapy "restaurant," epithelial tumors present this protein "menu" that helps T cells recognize them, while mesenchymal tumors hide it
What is MHC-1?
how many trainees in the lab hail from Canada?
2 (lynna and brian)
Tumors can downregulate these cell surface proteins that present antigens to T cells, making them invisible to the immune system
What is MHC?
Define the following slang: Rizz
Charisma, Likeable
Example: DiCaprio got that rizz yo
No wonder he's single, he's got no rizz
The cell-to-cell communication method Anushka primarily studied during her graduate studies
What is Notch Signaling?
These two checkpoint molecules are like bouncers or "brakes" on T cells.
What is PD-1 & CTLA-4?
Sunita’s project is to uncover microRNAs targeting CD73. How long is the average microRNA?
22 nucleotides (18-24 would be acceptable)
Some tumors express enzymes like IDO that deplete this essential amino acid, inhibiting T cell function
What is Tryptophan?
Define the following slang: Whack
Example: Man, that dude's tie is whack
Jesus, these western bands are whack
Anushka's favorite (alcoholic) beverage of choice
What is Rum?
When a tumor is responding to checkpoint inhibitors, it's like this type of financial transaction is being "cashed in" by the immune system.
What is Immune Deposit?
A sign reading “Caution: Fishing and Hunting stories in Progress- protective boots may be required. ” can be found on one of our trainee’s desks. Who is it?
Brian!
This process by which tumor antigens change over time helps cancer cells evade previously effective immune responses
What is Antigenic Drift/Shift?
*Immune Editing is also acceptable
Define the following slang: Ballin'
To do it BIG, living the good life/ living in affluence
We ballin' tonight bois - Anushka 08/03/2024
Back in her heyday Anushka was extremely passionate about the following career
What is Acting?
Anushka's research found that eliminating this enzyme, named after its molecular weight in kilodaltons, sensitizes tumors to immunotherapy
What is CD73?
Name the state that quasi-grad student, Lynna’s service dog Wyman now resides in
Texas :(
This oxygen-deprived tumor condition inhibits T cell function and promotes immunosuppressive cells like M2 macrophages
What is Hypoxia?
Use the slang in a sentence: Aura
Correct use should include someone losing/gaining socially perceived reputation.
Example:
A - Did you see that guy drop his groceries trying to carry it all in one trip?
B - Yeah man, dude lost so much aura
Anushka's favorite (non-alcoholic) beverage of choice
The Dongre Lab found that quasi-mesenchymal tumors recruit these special T cells that act like friendly restaurant critics, suppressing negative reviews and interference from the immune system
What is Tregs?
How many colors are on the largest flow panel that shiney has done
15 color panel... dawg....
This specialized population of suppressor cells, includes immature myeloid cells that strongly inhibit anti-tumor immunity
What are Myeloid-Derived Suppressor Cells?
Use the slang in a sentence: Chopped
Definition: Someone with an unkempt appearance
Example:
A - I heard the prof pulled two all nighters for that grant
B - Yeah I see those eye bags, man he's chopped