As seen on TV
Live life like you’re young: F. Scott Fitzgerald was the author of the 2008 film starring Brad Pitt “the Curious Case of Benjamin Button” where a child is born old and ages in reverse. Can you name a genetic condition in which rapid aging also occurs?
Progeria
Hutchinson-Guilford Progeria. This rare disease caused by a defect in the Lamin A gene leads to unstable nuclei causing signs of premature aging in children by age 2. The patients, unfortunately, have multiple medical conditions and often pass away young
This "C" trial showed there was no mortality benefit in ICU patients with hypovolemic shock, with the use of colloid vs crystalloids for fluid resuscitation
CRISTAL
Can you name 2 of the 3 Smoking-related ILD's
Bonus 100 points if you can name all 3
Respiratory-bronchiolitis—associated interstitial lung disease (RB-ILD)
Desquamative interstitial pneumonia (DIP)
If you suffered from amblygeusia, what infection would you be most worried about these days?
COVID-19
Amblygeusia refers to a diminution in the sense of taste one of the possible signs of COVID
The outbreak of this virus in pig farmers in Southeast Asia likely inspired the film "Contagion"
Nipah Virus
Named after this Renaissance polymath, active as a mathematician, astronomer, and Catholic canon, who formulated the heliocentric model of the universe, this trial showed that carvedilol reduced the risk of death in class 3 or 4 HFrEF.
COPERNICUS
Viral disease associated with lymphocytic interstitial pneumonia
EBV
A patient from S.E. Asia presents with 5 days of fevers, being the maverick diagnostician that you are, you perform the tourniquet test, what disease are you trying to look for?
Dengue Fever
In Death In Venice, composer Gustave Aschenbach travels to a Venice resort to escape personal and artistic stress. The last thing he expects is to encounter trouble, but his life is threatened when there is a sudden outbreak of this GI bug
Cholera
Named for this hircine zodiac sign this trial showed carvedilol is associated with decreased mortality in patients with acute MI and LV dysfunction.
CAPRICORN
Chemotherapy agent most commonly associated with ILD
Bleomycin, carmustine, busulfan, and cyclophosphamide
You see a patient who has returned from Uganda complaining of pain in his arm whenever he turns the key. What is the diagnosis?
African trypanosomiasis (sleeping sickness).
Kérandel symptom or ‘signe de la clef‘ named after Jean Francois Kérandel (1873-1934) is a sharp, deep pain in the bones or muscles when a patient with sleeping sickness turns a key in a lock.
Kerandel sign is a delayed hyperasthesia following a painful stimuli.
Both are two distinct symptoms of African human trypanosomiasis
Movie: The Secret Garden
Part of the movie focuses on Colin, a 10-year-old who has shut away in his room his entire life, we meet him unable to walk but after spending time in the titular secret garden and being exposed to proper sunlight, he regains the ability to walk. What disease could he have had?
Severe Vitamin D deficiency / ricketts / osteomalacia
A giant of the Baroque style, this Italian painter's name is also the title for this trial that showed Apixaban is non-inferior to dalteparin in treating cancer-associated VTE
CARAVAGGIO
UIP is not an ILD, it's a radiological or histological pattern. Can you name 3 of the 4 classic CT findings of UIP
Classic HRCT pattern including:
The boy Pharaoh Tutankhamun is the first person in history to have been proven to have this disease?
Malaria
Genetic tests in 2010 found multiple malarial infections in Tutankhamun making him the oldest know record of malaria in a human. Causes of his death and also his co-morbidities are vastly debated. The paper published in 2010 hypothesises he had avascular bone necrosis in conjunction with the malarial infection as the most likely cause of death.
Season 4, Episode 3, House MD "97 seconds"
Patient: 37 y/o M with spinal muscular atrophy, that keeps him confined to a wheelchair. He has severe ascending muscle weakness, 28% curvature of the spine, causing reduced lung capacity and reduced bone minimal density. He was constantly accompanied by a helper dog.
Presenting with syncope
Later developing pneumonia, dysphagia, lymphadenopathy
House Moment: Had recently traveled to Thailand
What infection did the patient have?
Strongyloides
Named for this creature from Greek mythology, this trial studied the effect of cyclophosphamide in ANCA associated vasculitis with renal involvement
CYCLOPS
Amiodarone is most commonly associated with Interstitial pneumonitis, but it is also associated with several other types of ILD presentation, what is the next most common ILD seen with Amiodarone
Organizing pneumonia (COP formerly BOOP)
From what animal can you catch Orf?
From a Sheep.
Orf virus is a DNA virus that belongs to the Parapoxvirus genus which occurs mostly in sheep and goats (and sometimes cattle).
Orf is a risk for sheep farmers, shearers, freezing workers, or anyone that bottle-feeds lambs. Children may also acquire it from playing on infected pasture or in a sheep shed. Butchers, meat porters and home cooks are sometimes infected from carcasses, especially sheep heads.