Gene-ie In A Bottle
This gene, located on chromosome 22, is thought to confer protection against African trypanosomes like the ones responsible for sleeping sickness, but have also been linked to increased risks for various kidney and hypertensive diseases.
What is apolipoprotein L1 (APOL1)?
This hybrid between IHD and CVVHDF provides for longer dialysis treatments while giving the ICU patient some downtime for procedures.
What is sustained low-efficiency dialysis (SLED)?
These proteins, presented on the surface of antigen presenting cells, function to determine "self" from "non-self".
What are human leukocyte antigens (or HLA)?
Because of renal retention of its metabolite, M6G, this analgesic should not be used in repeated doses in patients with renal failure.
What is morphine?
Philately refers to collectors of this object, a popular hobby dating back to the late 19th century.
What are stamps, or stamp collecting?
Despite being autosomal dominant, it is thought that two hits are required for the mutation in this gene to result in the most common inherited cause of renal failure in adults.
What is PKD1?
In chronic hemodialysis patients, ultrafiltration rates above this level have been associated with all-cause and cardiovascular mortality.
What is 13mL/kg/hr?
The complement pathway that is initiated spontaneously, by C3 conversion to C3b (unlike that that OTHER one that starts with C4...)
What is the alternative pathway?
This antihypertensive medication can cause drug-induced lupus or ANCA vasculitis.
What is hydralazine?
In the Star Wars franchise, this is the name of Luke Skywalker's home planet, famous for its twin suns.
What is Tatooine?
This is the most common renal complication of sickle cell disease and is most often heralded by overt nocturia.
What is a urinary concentrating defect?
Dialysis water systems must be routinely checked for this, which is found on the outer membrane of gram-negative bacteria.
What is lipopolysaccharide (LPS) endotoxin?
What is interleukin-2 (or IL-2)?
This anticonvulsant can cause metabolic acidosis without Fanconi syndrome through inhibition of carbonic anhydrase.
What is topiramate?
A futuristic society revolves around science & efficiency in this 1932 novel by Aldous Huxley.
What is Brave New World?
A male patient with hearing loss, hematuria, elevated creatinine, and a mother with hematuria likely has a mutation in this gene.
What is COL4A5?
Low-flux dialyzers that cannot clear middle-sized proteins such as beta-2 microglobulin can lead to the development of this potentially disabling condition?
What is dialysis related amyloidosis?
Autoantibodies against neural epidermal growth factor-like 1 protein is associated with this nephropathy.
What is membranous nephropathy?
This agent has a complex and interesting origin story, first discovered on Easter Island as an antibiotic produced by soil bacterium Streptomyces hydroscopicus and reportedly smuggled offsite during the Cold War, where it is now used in cancer treatment, immunosuppression, and potentially in anti-aging research.
What is rapamycin or sirolimus?
What are 20-sided dice (or d20 dice)?
Mutations in CACNA1S and SCN4A genes are the most commonly identified causes of this episodic condition.
What is hypokalemic periodic paralysis?
Hypernatremia in peritoneal dialysis can occur during rapid, frequent exchanges due to this phenomenon.
What is sodium sieving?
Calcineurin inhibitors prevent the nuclear translocation of this protein.
What is nuclear factor of activated T-cells, or NFAT?
This immunosuppressive agent targets the cell surface antigen CD-52.
What is alemtuzumab (Campath)?
This breakout Broadway hit stars a rotating cast in the titular role, whose premise is a spoof on history and the imagined rememberings of a famous former first lady.
What is Oh, Mary! ?