Pros not Amateurs
This drug was originally developed to stop morphine addiction, and well…. It certainly stopped people from using morphine.
This drug is deacetylated in the body by first pass metabolism.
What is Heroin?
This chemical does not survive long in the body because it is rapidly hydrolyzed.
What is Acetylcholine?
This non-essential amino acid is the precursor to Dopamine, Norepinephrine, and Epinephrine.
What is tyrosine?
These treat restless leg syndrome and Parkinson’s Disease. Examples include Pramipexole, Rotigotine, Cabergotine, and Bromocriptine.
What are dopaminergic agonists?
Serotonin is derived from this essential amino acid.
What is tryptophan?
Prodrugs are often designed to increase oral _____ examples include Olmesartan, Dabigatran, and Ramipril.
What is oral bioavailability?
The other name for muscarinic receptor antagonists including Atropine, Oxybutynin, and everyone’s favorite Diphenhydramine.
What is an Anticholinergic?
Agonists at this receptor site are used to treat shock, hypotension, and nasal decongestion. Examples include Phenylephrine and Methoxamine
What is alpha 1 agonists?
These drugs have Parkinsonian side effects with long term usage so while still used for some they largely have fallen out of favor.
What are typical antipsychotics?
Dr P is a big fan or very hopeful that these currently C-I controlled substances will be used for the treatment of PTSD and depression. Ex: Psilocybin, LSD
What are psychedelics?
Some prodrugs are designed to increase ______ allowing them to be used intravenously. Examples include: Fospropofol
What is solubility?
The common saying for identifying overdoses of this medication is: Red as a Beet, Dry as a Bone, Blind as a Bat, Hot as Firestone, and Mad as a Hatter.
What is Atropine (Anticholinergic/Muscarinic Antagonists)?
Antagonists to this receptor site are used as antihypertensives and Antiarrhythmics.
What is Beta 1 antagonists?
Amphetamine is an example of this type of drug.
What is Dopamine reuptake inhibitor?
These are the most common class of drugs for treatment of depression. Ex: Paroxetine, Fluoxetine, Duloxetine, and Citalopram.
What are serotonin reuptake inhibitors (SSRIs)/5-HT reuptake inhibitors?
Enhanced membrane permeability, enhanced solubility, targeted delivery and increased oral bioavailability.
What are advantages of using prodrugs?
These medications are often used a paralytics examples include succinylcholine and rocuronium.
What is Nicotinic Antagonists?
These medications which prevent the uptake of ______ are primarily used for depression, chronic pain, and ADHD. Examples include Methylphenidate, Duloxetine, andAmitriptyline.
What is Norepinephrine (NE) reuptake inhibitors?
These medications have become more popular for the treatment of schizophrenia and other psychoses in modern years.
What are atypical antipsychotics?
These drugs are often used an antiemetic agents. Ex: Ondanestron, Granisetron, and Metoclopramide.
What are 5-HT3 Antagonists?
This novel drug design is a unique and exciting method of treatment that’s getting a lot news attention.
What is Antibody-Drug Conjugates?
Sarin gas is an example of a an irreversible inhibitor of this enzyme which results in death.
What is acetylcholine esterase?
What is hypertension, arrhythmia, and benign prostatic hyperplasia?
666 Drugs
What are older generation typical antipsychotics?
These drugs often used for anxiety are unlike the other drugs in this category. Ex: Buspirone and Ipsaperone
What are 5-HT1A Partial Agonists?