Ethics
Stakeholders in drug discovery
[groups will get points for at least 4 correct answers] Patients, health of public, pharma companies, researchers, politicians, taxpayers
Thalidomide Risk
Causes severe birth defects when taken while pregnant
Applications of AI in drug discovery
High-throughput screening problems
Expensive, long (10-15 years), and high failure rate
5 requirements for a good target
[groups will get points for at least 2 correct answers] Closely related to disease, able to bind to other substances, easily modifiable, specific structure to help in the regulatory process, small molecules can bind to them
TrumpRX purpose
Offering (purportedly) the world’s lowest prices on prescription drugs
Years it took for the US to produce penicillin on an industrial scale (from time of first drug discovery)
[groups will get points for answers ± 10 years off] 136 years
Purpose of Novartis
Narrow down the target for autosomal dominant polycystic kidney disease; identify protein involved in Huntington's disease.
Cell-based assay screening advantages
Characterizes chemical compounds with unknown targets, targets that are unable to be purified, and different binding sites on the same receptor.
DARTS advantages
Easier & cheaper. Can be used for both complex cell lysates and purified proteins