Acetazolamide
The pharmacologic class of acetazolamide
What is carbonic anhydrase inhibitor?
The common dose of insulin and dextrose used in the treatment of hyperkalemia
What is 10 units IV push insulin regular and 50 mL of 50% dextrose (25g)?
If you have one of these two parameters you probably should not get PO N-ac, but IV N-ac
What are active vomiting and risk of aspiration?
Patients with a normal function of this organ can probably get appropriate AUC/MIC levels even with troughs <15
What is renal?
The only FDA-approved indication for Belsomra® (suvorexant)
What is insomnia?
The recommended dose of acetazolamide for metabolic alkalosis
What is 500mg IV x1 and reassess?
The titration parameter for insulin infusion when used for the treatment of BB and CCB overdose
What is maintaining an adequate systolic blood pressure?
Duration of time for a full IV and PO course of N-ac if no additional doses are needed
What are 21 hours and 72 hours?
Organ damage that can happen with supratherapeutic vancomycin doses
What is nephrotoxicity?
The recommended insulin dose range for hypertriglyceridemia induced pancreatitis treatment
What is 0.1 to 0.3 units/kg/hr continuous insulin infusion?
Allergies to this class of medications are of concern if giving acetazolamide
What are sulfonamides?
The expected drop in serum potassium after administering insulin and dextrose at the doses used for hyperkalemia
What is a drop in serum potassium of 0.5 to 1 mEq/L?
N-acetylcysteine helps in APAP overdoses by providing a precursor to this enzyme
What is glutathione?
Proxy used to estimate vancomycin AUC/MIC in clinical practice
What are vancomycin troughs?
The recommended warfarin INR goal for a patient with an On-X aortic valve replacement and no other thromboembolic risk factors
What is 1.5 to 2.0?
The type of surgery that acetazolamide is commonly given as a pre-operative medication in certain high risk patients
What is cataract surgery?
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The recommended bolus and initial infusion dose of insulin when used for the treatment of BB and CCB overdose by the expert consensus statement from the SCCM
What is 1 unit/kg bolus followed by infusion started at 1 units/kg/hr (initial infusion doses range from 0.1 to 1 units/kg/hr) (max up to 10 units/kg/hr)?
Amount of N-acetylcysteine in each oral solution vial
What is 2 grams?
Considered a therapeutic vancomycin AUC/MIC for MRSA infections with an MIC <1 mg/L
What is >400?
If your patient is taking a drug in this category, you should probably not recommend suvorexant (avoid use)
What is strong CYP 3A4 inhibitors?
The four FDA approved indications for acetazolamide
What are altitude illness, edema, elevated intraocular pressure, and epilepsy?
The recommended potassium level before giving the insulin bolus and the recommended level that potassium replacement is indicated during the infusion of high dose insulin for CCB and BB overdose
What is an initial potassium level of ≥3 mEq/L before the bolus and replacement indicated to maintain a level ≥2.8 mEq/L during high dose insulin continuous infusion?
Estimated cost savings per year at BUMCS if patients eligible for PO N-ac were started on it, instead of IV N-ac
What is >$30,000?
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This percentage of vancomycin is cleared renally
What is 70%?
Name of the new apixaban triple therapy versus dual therapy trial
What is the AGUSTUS trial?