Drug References
Database that contains information on drugs and other chemicals to which breastfeeding mothers may be exposed
What is LactMed?
Increasing ___ correlates to the ability to have a lower alpha, lower beta, smaller effect size of statistical significance, and lesser variance in observed effect
What is sample size?
Best quality of evidence based on hierarchy of evidence pyramid
What are systematic reviews and meta-analyses (of RCTs)?
A dose of ondansetron in the last 24 hours
What is one of the exclusion criteria for automatic IV to PO conversion?
Performance improvement tool that is a focused effort to evaluate medication use processes or medication treatment response with the goal of optimal patient outcomes
What is a medication use evaluation (MUE)?
This resource maintained by the National Library of Medicine is a good place to find package inserts
What is DailyMed?
Risk of an individual having an event given that the patient has not had an event up to a specific point in time
What is hazard ratio?
Concludes that there is no association when there is actually one (fails to reject a null hypothesis)
What is type II error/false negative?
Giving a dose of vancomycin then waiting for about 24 hours, drawing a level, and re-dosing if the level is < 15 mcg/mL
What is pulse or PRN vancomycin dosing?
Incorrect rejection of a true null hypothesis
What is a type I error/false positive?
Determine if it is safe for the mother to breastfeed after receiving IV digoxin
What is avoidance of breastfeeding for 2 hours after the dose of IV digoxin?
56 volunteers were given new drug, 14 had upset stomach. Among 85 volunteers who did not take the medication, 2 had upset stomach. Calculate RR
What is 10.4?
Established inpatient blood glucose goals as 140-180 mg/dL
What is NICE-SUGAR?
A reason to change a person from vancomycin to nafcillin
What is a culture result of MSSA?
A resident physician calls and asks you if it is safe to start valproic acid for a patient with bipolar disorder who is 16 weeks pregnant. What is your recommendation and what resource did you use?
No, VPA is a teratogen
Briggs Drugs in Pregnancy and Lactation within Lexicomp
AB is a 7 day old baby girl (gestational age = 38 weeks) with bacteremia, group B Streptococcal disease. Determine the dose, frequency, and duration of ampicillin for her treatment.
What is 50mg/kg/dose IV every 8 hours for 10 days?
Neofax
In a study, the risk of death in the treatment group was 28% (18 deaths among 64 patients), and in the control group was 44% (29 deaths among 75 patients). Determine absolute risks of death.
What is 0.16 (16%)?
Treatment reduces the absolute risks of death by 16% as compared to control
Established the benefit of sacubitril/valsartan over enalapril in patients with HFrEF
What is the PARADIGM-HF trial?
55 years old male, 67kg, CrCl 100ml/min, treated empirically with vancomycin for sepsis. Calculate the loading dose and maintenance dose.
What is 1750mg once, then 1000mg q12h?
One of your patients give you a list of her home medications, which includes baclofen, sertraline, and amlodipine. Her PMHs are hypertension, depression, and liver disease. She asks if she can take kava kava to get a better sleep at night. What do you recommend and what source do you use?
What is Livertox?
Calculate the rate of maintenance fluid in a pediatric patient that weighs 11.5kg. Hint: use Lexicomp
What is 44.8 ml/hr?
Interpretation of odds ratio =2
Those who were exposed to the factor had two times the odds of having the outcome compared to those who were not exposed to the factor
Designs in which a targeted therapy is evaluated on multiple diseases that have common molecular alternations
What is BASKET trial?
What is the duration of treatment with antibiotics for an adult patient with infective endocarditis involved a prosthetic valve caused by Viridans group streptococci?
What are 6 weeks?
A nurse calls you and asks if she can Y-site furosemide with the midazolam continuous infusion that is currently running for her patient in the neuro ICU. What do you tell her and what resource did you use?
No
Trissel's within Lexicomp