MOA
What is the MOA of Norepinephrine
a1, a2, B1, B2 agonist
The MOA for this drug is B2 partial agonist
Albuterol
1-transmembrane, 7-transmembrane, Ion channels, Intracellular receptors (Nuclear receptors)
What are the three types of MOA
Agonist, Antagonist, Allosteric
What are examples of intracellular receptors and transcriptional regulators
Steroids and horomones
What is the MOA of Metoprolol
B1 antagonist (reversible)
The MOA for this drug is a1 and a2 antagonist (irreversible)
Phenoxybenzamine
Baroreceptors are what type of sensitive
Pressure
What are key points about fish oil
Ion channels are in what cells
all cells
What is the MOA of Diazepam
GABA receptor allosteric agonist
The MOA for this drug is H1 and H2 receptor agonist
Histamine
Are ligand channels normally open or closed and which way do they move ions
Usually closed and move ions against concentration gradient
What is important about Vitamin D
Linked to proper brain function, blood sugar, CV, bone health. High/extreme levels can cause kidney failure, arrhythmias, and even death
Increase in nerve firing
What is the MOA of Varenicline
Nicotinic receptor (Nn) partial agonist
The MOA for this drug is B1 and B2 partial agonist
Pindolol
What is the largest single class of pharmacological receptor
7-transmembrane
What is a type of 1-Transmembrane protein
Tyrosine kinases
In 7-transmembrane proteins alterations in the G-protein expression can play an important role in what
Disease
What is the MOA of Tropicamide
Muscarinic (M1, M2, M3) antagonist (reversible)
The MOA for this drug is a1 antagonist (reversible)
Prazosin
GPCR (G-protein coupled receptors) are defined and regulated by what
a subunit
What are types of 7-transmembrane proteins
GPCR
-a and B adrenergic, 5HT, Histamine
What type of channel is highly selective and only open at a certain membrane potential
Voltage gated