Pulmonary Hypertension
Riociguat directly stimulates this enzyme to increase cGMP.
What is guanylate cyclase.
In patients with pulmonary hypertension that are no vasoreactive use of this drug is contraindicated.
What are calcium channel blockers.
In allergic rhinitis, these histamine receptor subtypes are targeted.
What are H1 receptors.
What is the NMDA receptor. (agonist at sigma 1 receptor).
B2 agonists increase efflux of which ion?
K+
Riociguat is contraindicated in patients taking this class of drugs.
What are PDE-5 inhibitors --> too much vasodilation
Monthly labs should be order for endothelin receptor antagonists to check these two things.
Liver function - drug is hepatotoxic
Pregnancy test.
What is cross the blood-brain-barrier.
This drug thins and looses mucus secretions in the airways.
What is guaifenesin. *do not use for persistent cough from long term problems)
Prostacyclin is derived from this arachidonic acid pathway.
What is cyclooxygenase.
This drug antagonizes the effects of acetylcholine.
What is ipratropium bromide.
Prostacyclin inhibits this.
What is smooth muscle proliferation.
This drug can cause nasal stinging.
What is cromolyn (mast cell stabilizer).
Severe COPD should be treated with a drug that acts by doing this.
Roflumilast - inhibition of PDE-4
What is jaw pain.
This drug can cause rhinitis medicamentosa.
What is oxymetazoline (Afrin) - alpha 1 agonist (vasoconstriction).