Drugs

Dersch Booo

100

When drug causes an increase in the number of enzyme molecules 

Barbiturates, polycyclic aromatic hydrocarbons and examples of this

inducers 

200

It is not possible to achieve a steady state concentration for drugs with this type of clearance

Double Jeopardy: Name an example

Zero Order clearance 

Bonus Points: Ethanol

300

What Reaction is shown here?

Azo Reduction

400

What two reactions are shown here?

N-Dealkylation

O dealkylation

500

This isozyme of CYP is the most likely to have drug interactions. It also metabolizes the largest percentage of drugs in CYP450

CYP3A4/5

Cancer Drugs

100

This drug inhibitis dihydrofolate reductase

Methotrexate 

200

These drugs work by forming a platinum-DNA adduct that impairs DNA replication leading to cell cycle arrest. Name the two drugs from this category

Carboplatin and Cisplatin

300

cyclophosamide is used in invasive breast cancers, leukemia multiple myeloma and ovarian cancer and works by this mechanism of action

inter and intra strand binding of purine bases leading to DNA damage and Apoptosis

(alkylators)

400

Both Vincristine and Paclitaxel cause what kind of toxic/adverse side effect

Bonus Points: What class of drugs are these

Peripheral Neuropathy

Microtubule Binding drugs 

500

This antibody therapy causes cardiotoxicity, pulmonary toxicity, embryofetal toxicity and infusion reactions. What receptor does this medication bind to?

Binds to HER2

Med: Trastuzumab

Pharmaco-dynamics

100

Inverse agonists stabilize the () form of the receptor

inactive

200

A maximal biological response is still achieved without full occupancy of a drug in its target

commonly seen in hormones and neurotransmitters, 

receptor reserve/spare receptor

300

Non competitive agonists have what effect of E50 and Maximal Response

E50-no effect

Maximal Response-diminished

400

Reduced drug effectiveness and tolerance is mediated through this process. 

Hint: seen on beta adrenergic receptors 

Down regulation of beta adrenergic receptors through internalization and degradation by lysosomes 

500

The red curve represents the addition the addition of a particular drug in cholinergic receptors. Name this drug. 

Atropine 

anticholinergic i.e acetylcholine antagonist 

Toxicology

100

True or False: Vomiting is the first line of treatment when dealing with a poisoning. 

FALSE

200

A high dose of O2 or a hyperbaric chamber is used to treat this poisoning 

CO 

300

This medication is used to treat acetaminophen overdose. 

Double Jeopardy: Name the drug and the time frame it must be given in

N-acetylcysteine 

Within 36 hrs of injestion

400

Neuological Symptoms such as visual losses, ataxia, hearing loss, decreased cognition are symptoms of this type of poisioning. This is treated by

Partial credit, name the poisioning

Chelation therapy with dimercaprol, penicillamine, succimer

 

Mercury Poisoning 

500

Exposure to large amounts of this leads to this condition. 

TCDD

Cancer Drugs 2

100

Imatinib is a targeted therapy used in leukemias and GIST. What class of cancer therapy does imatinib fall into?

Tyrosine Kinase Inhibitors 

200

These two hormone modulators are antagonists that inhibits binding to the androgen receptor and are commonly used in the treatment of metastatic prostate cancer 

Flutamide and Enzalutamide

300

These two drugs work by generating DNA strand breaks by interfering with Topo 2

Doxorubicin, Etoposide

400

This CTLA-4 antagonist is used in the treatment of melanoma, renal cell, colorectal, hepatocellular and esophageal cancers. It can cause these side effects (name 3)

Immune mediated dermatitis colitis, enterocolitis, fatigue, diarrhea, rash, itching, musculoskeletal pain, embryo-fetal toxicity 

Drug-Ipilimumab

500

Lenalidomide

Name Mechanism of Action and two side effect 

Immunomodulator that binds to CRBN E3 ubiquitin-ligase

Side effects: Rash, myelosuppression, fatigue, embryofetal toxicity, risk of myocrardial infarction and stroke 

Which drug would you wanna take?

100

A drug that can be reversed with Naloxone (Narcan)

Opioid (morphine, heroin, fentanyl) 

200

Antidote for Cyanide Poisioning

hydroxocobalamin (Vit B12)

300

This herbal supplement is used to treat opiod withdrawals and pain. Its adverse effects are seizures, psychosis and addiction

Kratom

400

This herbal supplement is an inducer of CYP3A4 and used to help treat depression. name one other med that is contraindicated when taking this supplement

Possible Answers:

OCPs, Digoxin, Warfarin, Cyclosporine

Herbal Supplement: Saint John's Wort 

500

This drug is an inhibitor of Vitamin K dependent reactions. 

What are the two genotypes to consider when dosing this medication? 

VKORC1 and CYP2C9

Misc

100

This phase of clinical trials employs healthy volunteers to determine the safety of the drug

Phase 1 clinical trial

200

This is an inhibitor of 

CYP 34A

300

This Baddie is on a med for ADHD that does not have any refills allowed. Name the drug category (classification) according to the controlled substance act

Bonus Points to anyone who can identify the max daily supply for these type of meds

Schedule II

90 day max supply 

(which actually isnt always true... some practices only give you 30 day supplies, my neuropsych dr only does 28 day supplies) 

400

Primaquine, nitrofurantoin, naphthalene and fava beans are contraindicated in patients with this condition

G6PD deficiency

500

This condition results in prolonged paralysis after anesthesia  

Name the drug and the condition

Double jeopardyyyyy

Pseudocholinesterase Deficiency 

Drug: Succinylcholine