Show:
Targeted Therapies
Interferons and
Interleukins
Colony-Stimulating
Factors (CSFs)
Erythropoietin Simulating Agent and
Thrombopoietic Growth Factor
Granulocyte Colony-Stimulating Factor and
Granulocyte Macrophage Colony Stimulating Factor
100
New approach to cancer treatment that interferes with cancer cell growth and division at various points in the development, growth, and spread of cancer. It is controversial due to the cost of treatments.
What is targeted therapy?
100
Bind to specific receptors on cancer cell membranes and suppress cell division, enhance the phagocytic activity of macrophages, and promote the cytotoxic activity of T lymphocytes.
What is the function of interons?
100
Proteins that stimulate/regulate the growth, maturation and differentiation of bone marrow stem cells.
What are colony-stimulating factors?
100
Stimulates RBC production in response to hypoxia.
What is Erythropoietin?
100
Regulates the production of neutrophils (WBCs) within the bone marrow.
What is granulocyte colony stimulating factor?
200
dasatinib (Sprycel), imatinib mesylate (Gleevec); used to treat chronic myelogenous leukemia, can control but not eradicate the disease, grapefruit juice increases serum concentration of the drug
What are 2 tyrosine kinase inhibitors?
200
Complex proteins produced by the cells of the immune system, used to enhance host immune system, and destroy/interfere with tumor activities. They include interferons, interleukins, and colony-stimulating factors.
What are biologic response modifiers (BMRs)
200
Watch Hgb and Hct because they increase with this drug.
What is epoetin alfa (Procrit)?
200
Imperative to watch Hgb (should not exceed 12g/dl due to risks of death) with the use of this drug.
What is epoetin alfa (Procrit)?
200
Common granulocyte colony stimulating factor.
What is filgrastim (Neupogen)?
300
bortexomib (Velcade)
What is 1 Proteasome inhibitor?
300
Interferon-alpha, interferon beta, and interferon gamma
What are some major interferons of the BRMs?
300

Decreases the length of post treatment neutropenia, permits delivery of high dose drugs, reduces bone marrow recovery time, enhances macrophage destroying ability, and prevents severe thrombocytopenia after myelosuppressive therapy.

What is the therapeutic effects of Colony stimulating factors?

300
HTN, HA, arthalgias (joint pain), injection site reactions
What are side effects of Procrit?
300
Stimulates macrophage production.
What is granulocyte-macrophage colongy stimulating factor?
400
cetuximab (Erbitux), and trastuzumab (Herceptin)
What are 2 Epidermal growth factor/receptor (EGRF) inhibitors?
400
Side effect of interferons.
What is flulike symptoms.
400
Erythropoietin, Granulocyte Colony-Stimulating Factor, Granulocyte-Macrophage Colony-Stimulating Factor, and Thrombopoietic Growth Factor.
What are some colony-stimulating factors approved by the FDA for clinical use?
400
A thrombopoietic growth factor indicated to prevent severe thrombocytopenia and to reduce the need for platelet transfusions following myelosuppressive chemo.
What is oprelvekin (Neumega)?
400
A common granulocyte-macrophage colony stimulating factor.
What is sargramostim (Leukine)?
500
A vascular endothelial growth factor/receptor (VEGRF) inhibitor that inhibits blood vessel formation for tumors.
What is bevacizumab (Avastin)
500
Capillary leak syndrome and infection are serious adverse reactions to these.
What are interleukins?
500
Watch for cardiac/pulmonary system symptoms
What is a concern with sargramostim a granulocyte-macrophage colony-stimulating factor?
500
Serious fluid retention, perifperal edema, exertional dyspnea, ascities, papilledema, increased BP, Crackles, JVD, decreased electrolytes, blurred vision and pressure around the eyes.
What are some side effects of Neumega?
500
Dyspnea, pulmonary disease, and cardiac disease, and an increase in symptoms in patient's with pre-existing respiratory and cardiac issues.
What are side effects of Leukine?