Direct-acting muscarinic
direct-acting muscarinic
acetylcholine
irreversible indirect-acting
severe bronchoconstriction, hypotension, bradycardia, miosis
Organophosphate
Antidote for cholinergic agonists
Atropine
What drug could be used to treat a tumor-producing epinephrine: pheochromocytoma?
Phenoxybenzamine
Nm- Nicotinic muscular receptors
where is it found? effects?
found in neuromuscular junction
(effects: depolarization leading to leading to skeletal muscle contractions)
Treats Urinary retention
Bethanechol
bradycardia, miosis, bronchoconstriction, urinary incontinence, neuromuscular effects
Which drug can be considered poison when too much is given.
Organophosphate
Preanesthetic use
Glycopyrrolate (Robinul-V)
Atropine has no effect for which animal
Rabbits
Muscarinic receptors activating the Gq protein
M1, M3, M5
treats acute and chronic glaucoma in dogs
Pilocarpine
bradycardia, miosis, bronchoconstriction, urinary incontinence, neuromuscular effects
reversible indirect acting
treats myasthenia gravis (2 possible answers)
Neostigmine
Pyridostigmine
Used to prevent motion sickness
Scopolamine
In a clinical case of navicular disease condition of horses, what drug is used to treat the affected horses?
Isoxsuprine
Nn- Nicotinic neuronal receptors
where is it found
found in autonomic ganglia, adrenal medulla and CNS
Treats GI paralytic ileus (ONLY when no mechanical GIT obstruction)
Bethanechol
bradycardia, miosis, bronchoconstriction, urinary incontinence, neuromuscular effects
reversible indirect acting
treats glaucoma
used as smooth muscle relaxants
Scopolamine butylbromide (Buscopan)
Which drug has both muscarinic and nicotinic effects?
Acetylcholine
Muscarinic receptors - Gi protein, inhibition of adenylyl cyclase, activation of receptor operated K+ channels
M2, M4
direct-acting
treats keratoconjunctivitis sicca
Pilocarpine
bradycardia, miosis, bronchoconstriction, urinary incontinence, neuromuscular effects
reversible indirect acting
reverse neuromuscular blockade
Edrophonium
2 options
mydriasis & cycloplegia
Tropicamide & Homatropine
An english bulldog is suffering from severe hypotension during the pre-anesthetic procedure caused by the administration of an a2-adrenergic receptor agonist. What drug will you use to reverse this side effect?
Atipamezole
What sympathomimetic drug can be used as part of the treatment of acute congestive heart failure in dogs?
Dobutamine