500
A 27 yo man is brought to the ED by his best friend. As per his friend the patient was found this morning wandering the streets and appeared to have been robbed. Friend states patient seems very odd, and at times appears to be "listening to something". You evaluate the patient and observe a drowsy disoriented man with a BP of 110/80 Pulse 89 bpm pupils are mildly dilated, mucous membranes appear to be dry. During your evaluation you notice that the patient is very subdued and follows all the instructions that you give him without any opposition, even uncomfortable aspects of the exam are followed without questioning, you find this interesting and decide to ask the patient to get one one leg and jump, patient immediately does this, you attribute this odd finding to his current condition and begin supportive treatment. A few hours later the patient is reevaluated he is now appearing to be normal and states he does not remember anything from the previous night or earlier this morning, he does however state he can remember getting ready to go out for drinks with some friends the night before. With this information which is the best diagnosis you can give at this time?
a. Cannabis intoxication b. Opioid intoxication c. Other (or unknown) substance intoxication d. Stimulant intoxication e. Hallucinogen intoxication
What is Answer is C. In order to answer this question you must go through a process of elimination. Cannabis intoxication: you can see motor impairment, euphoria and anxiety, on physical exam you may see conjunctival injection and tachycardia which our patient does not have, and you can find dry mouth, cannabis would not explain the lack of “free will” that our patient shows and it would not impair memory. Opioid intoxication you would see myosis, rarely mydriasis, drowsiness and slurred speech. You may see impairment in memory and rarely hallucinations. In stimulant intoxication: psychomotor agitation, nausea or vomiting, bradycardia or tachycardia, elevated or low blood pressure, you may see confusion but again not behavior as presented by this patient. Hallucinogen intoxication you can appreciate anxiety, paranoia, pupillary dilation, tachycardia tremors and incoordination.
The patient from our case presents with some anticholinergic symptoms, impaired memory, questionable hallucinations and odd behavior, the diagnosis is Scopolamine intoxication. Scopolamine is not a well known substance in US, it has medical indications for Nausea and is available by transdermal patches. In South America specially in Colombia Scopolamine is used as a drug to commit crime and is usually either blown to a persons face or administered in their drinks. It is a drug of choice for robbery as patients present total lack of free will and obey every command that is given, facilitating crime. Scopolamine intoxication may present also with some anticholinergic side effects and at large doses these will be more prominent. Hallucinations may also occur.
As this substance is not well known and not part of the substances listed in DSM 5 the correct answer will be Other (or unknown) substance intoxication. The importance of this question is to be aware of some of the most popular drug intoxication side effects but at the same time be cognizant of the possibility of rare or unknown drugs.