Statins
These two statins are considered high-intensity when used at appropriate doses.
What are atorvastatin and rosuvastatin?
This percentage reduction in LDL-C is expected with high-intensity statin therapy.
What is at least a 50% reduction?
This cardiovascular risk calculator replaced the Pooled Cohort Equations in the 2026 dyslipidemia guideline.
What are the Predicting Risk of Cardiovascular Disease Events PREVENT-ASCVD equations?
PCSK9 inhibitors generally reduce LDL cholesterol by approximately this percentage.
What is about 50-60%?
This medication is generally the first non-statin therapy added when LDL-C remains above goal despite maximally tolerated statin therapy and is expected to lower the LDL-C by 15%-20%.
What is ezetimibe?
This laboratory value should be obtained if a patient develops severe muscle pain or weakness while taking a statin.
What is creatine kinase (CK)?
This LDL-C goal is the treatment target for patients with PREVENT intermediate ASCVD risk.
What is LDL less than 100 mg/dL?
The 2026 guideline recommends measuring this biomarker at least once during adulthood.
What is lipoproteinA?
These two monoclonal antibodies inhibit PCSK9 and are administered by subcutaneous injection.
What are Repatha (evolocumab) and Praluent (alirocumab)?
A patient with triglycerides of 650 mg/dL despite lifestyle modification is most likely to benefit from this class of medications to reduce pancreatitis risk.
What are fibrates?
These are the only two statins classified as hydrophilic and may be considered in patients who experience statin-associated muscle symptoms.
What are rosuvastatin and pravastatin?
These Non-HDL-C and LDL-C goals are recommended for secondary ASCVD prevention in patients with a very high ASCVD risk.
What is LDL less than 55 mg/dL and what is Non-HDL-C less than 85 mg/dL?
The 2026 guidelines recommend LDL-lowering independent of baseline LDL-C in adults ages 40-75 with these disease states.
What are diabetes, CKD stage 3 or 4, and HIV?
Following the initial and 3-month doses, this lipid-lowering medication is administered every six months.
What is inclisiran?
This medication increases uric acid and is expected to lower LDL-C by approximately 20%.
What is bempedoic acid?
This statin is metabolized primarily by CYP3A4 and has one of the highest potentials for drug-drug interactions.
What is simvastatin?
These Non-HDL-C and LDL-C goals are selected for certain patients for primary ASCVD prevention in patients with a VERY high ASCVD risk.
What is LDL-C less than 70 mg/dL and what is Non-HDL-C less than 100 mg/dL?
This protein is now recommended to be measured in adults on lipid-lowering therapy, particularly those with ASCVD, cardiovascular kidney metabolic syndrome, type 2 diabetes, and/or elevated triglycerides to help guide further therapy once LDL and HDL goals have been achieved.
What is ApolipoproteinB/ApoB?
This rare genetic disorder is the FDA-approved indication for Evkeeza (evinacumab).
What is homozygous familial hypercholesterolemia (HoFH)?
This medication demonstrated cardiovascular benefit in statin-treated patients with elevated triglycerides in the REDUCE-IT trial.
What is Vascepa (icosapent ethyl)?
These four statins are generally recommended to be taken in the evening because of their relatively short half-lives.
What are simvastatin, lovastatin, fluvastatin, and pravastatin?
This percent LDL-C reduction is recommended for patients with Intermediate PREVENT-ASCVD Risk estimates.
What is at least a 30% LDL-C reduction?
The updated guidelines recommend using one of these 2 equations rather than the previously used Friedewald formula to estimate LDL-C in adults and children who have undergone a standard lipid profile.
What are the Martin/Hopkins equation and the Sampson/NIH equations?
This first ever FDA-approved oral PCKS9-Inhibitor was developed by Merk.
What is Lipfrenda (enlicitide)?
A patient develops muscle symptoms on multiple statins despite rechallenge. This oral medication demonstrated cardiovascular benefit in statin-intolerant patients in the CLEAR Outcomes trial.
What is bempedoic acid?