DAWWAS
In the Dawwas presentation, the rate of recurrent bleeding in the Xarelto arm was ______
What is 5.53
In AMPLIFY what dose of enoxaparin was used?
What is 1 mg/kg
Breast-feeding is not recommended during treatment with Eliquis.
True or False?
True
In the Dawwas presentation, the HR for the effectiveness endpoint ____
What is 0.37 HR
In the ARISTOPHANES analysis, in which of the 3 cohorts did Eliquis have the lowest rate of stroke and systemic embolism and what was the rate?What is 1.12%
What is Eliquis vs. Pradaxa 1.12%
One of the exclusion criteria in the Dawwas analysis with patients who did not initiate study drug within _____ days of their diagnosis
What is 30 days
In AMPLIFY what was the rate of ‘all bleeding‘ in the Eliquis arm?
What is 15%
True or false?
You may have a higher risk of bleeding if you take Eliquis with selective serotonin reuptake inhibitor’s (SSRIs)or serotonin norepinephrine reuptake in Hibbett her’s (SNRIs)
True
How was APPRAISE -2 described in the Dawwas presentation? Which patients? Which competitors?
A placebo controlled trial of Apixaban and high risk post acute coronary syndrome treated with the aspirin or the combination of aspirin and clopidogrel
What was the total study population in ARISTOPHANES?
What is 434,046 pts
In the Dawwas analysis, the mean age of Eliquis patients after PSM was ____
What is 61.6
There were _______ patients randomized in the Eliquis arm of the amplify
What is n=2693
Eliquis should be decreased by _____ when administered with drugs that are combined P-gp and strong CYP384 inhibitors
What is 50%
What was the rate of minor bleeding outcomes in the Eliquis arm in the Dawwas presentation?
What is 19.79%
Which databases were used in the ARISTOPHANES analysis?
What is Truven, IMS Pharm metrics, Optum, Humana research
The percentage of Eliquis patients in the Dawwas analysis with unprovoked DTE was ___
What is 50.9%
In amplify, a transfusion of _____ or more units of packed red blood cells along with clinically overt bleeding was considered major bleeding
What is transfusion of two or more units of PRBC along with clinically overt bleeding was considered major bleeding
Name 3 CYP3A4 inhibitors
What is Ketoconazole, Itraconazole, Ritonavir
How many Apixaban patients and how many Rivaroxaban patients were in the study?
What is 3,091 Apixaban patience and 12,163 Rivaroxaban patients
How many patients in the Eliquis arm of the Eliquis versus warfarin cohort received the lower dose of Eliquis?
What is 25,578
In that Dawwas presentation, the Cl for the safety and point was _____
What is 0.37-0.82
Indwelling epidural or intrathecal catheters should not be removed your earlier than ______ after the last administration of Eliquis
What is 24 hours
Clarithromycin is a combined P-gp and strong CYP 384 inhibitor. Pharmacodynamic data suggests that ____ is necessary with concomitant administration with Eliquis
No dose adjustment
What was the outcome of this study?
The study found a lower risk of recurrent Venus thromboembolism, major bleeding events, and minor bleeding events with the use of a Apixaban compared to Rivaroxaban.
What percentage of patients in the Eliquis arm of Eliquis versus Xarelto cohort had diabetes?
What is 34.4%