DEVELOPMENTAL TIMELINE
GERM LAYERS
CRANIOFACIAL DEVELOPMENT
DEVELOPMENT OF MAXILLA / MANDIBLE
PHARYNGEAL ARCHES
100

Occurs at the end of Week 1 and involves attachment to the endometrium.

What is implantation?

100

This germ layer forms enamel.

What is ectoderm?

100

Cleft lip results from failure of fusion of these two processes.

What are maxillary and medial nasal processes?

100

This forms a cone-shaped mass that occupies most of the  developing ramus.

What is condylar cartilage?

100

The arches that appear as bulges on the lateral aspect of the embryo.

What are branchial or pharyngeal arches?

200

The primitive streak appears during this week.

What is week 3?

200

This cell population forms dentin and pulp.

What are neural crest cells?

200

The secondary palate develops from these structures.

What are palatal shelves of the maxillary processes?

200

This cartilage serves as a template for mandibular development but does not directly become the mandible.

What is Meckel’s cartilage?

200

The second pharyngeal arch is also known by this name.

What is the hyoid arch?

300

Neural tube closure is completed by the end of this week.

What is week 4?

300

Skeletal muscles originate from this layer.

What is mesoderm?

300

This arch contributes to the mandible.

What is the first pharyngeal arch?

300

The mandible develops by this type of ossification.

What is intramembranous ossification?

300

Muscles of facial expression develop from this arch.

What is the second pharyngeal arch?

400

This period (Weeks 3–8) is the most critical for organ formation.

What is the embryonic period?

400

The thyroid gland is derived from this germ layer.

What is endoderm?

400

This structure guides midline facial development.

What is the frontonasal process?

400

The maxilla forms from this embryonic prominence.

What is the maxillary process?

400

Failure of proper development of the first arch may result in this condition characterized by mandibular hypoplasia.

What is Treacher Collins syndrome?

500

A solid ball of cells resulting from division of a fertilized ovum.

What is a morula?

500

During the 8th day - 2nd week, the embryo develops into a 2-layered disk. 

What is bilaminar germ disk?

500

The failure of central fusion of mandibular prominences.

What is gnathochisis?

500

This mechanism explains how the mandible forms lateral to Meckel’s cartilage without replacing it.

What is intramembranous ossification around Meckel’s cartilage?

500

This embryonic cell population migrates into the pharyngeal arches and contributes to craniofacial skeleton formation.

What are neural crest cells?