Antidote Alley
This antidote is titrated to reverse respiratory depression and restore protective airway reflexes in opioid overdose, with an initial adult dose of 0.2-2 mg IV/IM or 2 mg IN/neb.
What is naloxone?
This induction agent and dose is commonly used for pediatric rapid sequence intubation due to its rapid onset, brief duration of action, and lack of significant hemodynamic compromise. However, this agent does have a risk of causing adrenal suppression.
What is etomidate 0.3 mg/kg IV?
For DVT treatment in renal failure (CrCl <30 mL/min), reduce this subcutaneous anticoagulant from 1 mg/kg Q12H to 1 mg/kg Q24H for non-obese patients.
What is enoxaparin (Lovenox)?
This commonly used over-the-counter pain reliever became the center of controversy after claims suggested prenatal exposure may be linked to autism.
What is acetaminophen (Tylenol)?
Combining MAOIs, SSRIs, and certain opioids can cause this life-threatening syndrome.
What is Serotonin Syndrome?
This antidote is given at 5 g as a single infusion over 15 minutes for adults (70 mg/kg for pediatrics) to treat cyanide poisoning and may cause transient hypertension.
What is hydroxocobalamin?
For pediatric septic shock, this initial fluid bolus volume is recommended, administered rapidly and repeated as needed based on clinical response.
What is 20 mL/kg of isotonic crystalloid fluids?
For stress ulcer prophylaxis in renal impairment (CrCl 30-60 mL/min), reduce this agent from 40 mg/day to 20 mg/day.
What is famotidine (Pepcid)?
This class of antibiotics is believed to be contraindicated and commonly avoided in patients with penicillin allergies.
What are cephalosporins?
This is the effect on INR when patients who are on warfarin are prescribed amiodarone
What is an increase in INR?
This antidote is indicated for recurrent or dextrose-refractory hypoglycemia often caused by sulfonylureas.
What is octreotide?
This commonly used antibiotic can displace bilirubin and increase the risk of kernicterus in neonates.
What is ceftriaxone?
For treatment of influenza in a patient with a CrCL between 10-29, reduce this agent from 75 mg PO Q12H to 30 mg PO Q24H.
What is oseltamivir (Tamiflu)?
Despite weak and inconsistent evidence for a true disulfiram-like reaction, patients are routinely counseled to avoid alcohol with this antibiotic used for anaerobic and protozoal infections.
What is metronidazole (Flagyl)?
Coadministration of this muscle relaxant with ciprofloxacin is contraindicated due to CYP1A2 inhibition, causing hypotension, bradycardia, and CNS depression with two reported fatal outcomes.
What is tizanidine (Zanaflex)?
This rescue therapy is recommended for local anesthetic systemic toxicity in patients with seizures or impending seizures and/or life-threatening cardiovascular instability, including arrhythmias, severe hypotension, or cardiac arrest.
What is intravenous lipid emulsion?
This is the magnesium sulfate weight-based dose for pediatric status asthmaticus.
What is 25 to 75 mg/kg/dose (Max dose: 2000 mg/dose)?
In patients with a CrCl <29 mL/min, reduce this cephalosporin from 2 g IV Q8H to 1 g IV Q12H when indicated for Pseudomonal endocarditis.
What is cefepime?
Despite traditional teaching, recent evidence shows this drug class demonstrated no increased adverse events in cocaine-associated chest pain, though benzodiazepines and nitrates remain first-line
What are beta blockers?
This antiepileptic medication potentiates adenosine's effects through A1 receptor upregulation, leading to a potential increased risk of bradycardia or heart block.
What is carbamazepine (Tegretol)?
This antidote reverses anticholinergic delirium but is contraindicated in TCA overdose due to the risk of seizures and dysrhythmias.
What is physostigmine?
This is the weight-based dose of epinephrine given every 3-5 minutes during pediatric cardiac arrest.
What is 0.01 mg/kg (0.1 mL/kg of the 0.1 mg/mL concentration; Max dose 1 mg)?
This is the dose adjustment for apixaban (Eliquis) for a 85 year old female, 65 kg, with a SCr 2.0 mg/dl for the indication of DVT/PE.
Dose Adjustment Criteria: Age greater than or equal to 80 years old, Body weight less than or equal to 60 kg, Creatinine greater than or equal to 1.5 mg/dl
What is no dose adjustment?
Traditional teaching warns against giving this electrolyte for hyperkalemia in digoxin toxicity due to "stone heart" theory, though modern evidence suggests this contraindication is likely unfounded.
What is calcium?
Iron supplements chelate this antibiotic class, reducing absorption by up to 90% and causing treatment failure even when doses are separated by several hours.
What are fluoroquinolones or tetracyclines?