The time the patient receives Zaltrap relative to the FOLFIRI
What is one hour prior?
100
The amount of time Zaltrap should be suspended prior to surgery
What is 4 weeks?
100
Patients were excluded from the TML trial if they had first line progression free survival less this
What is 3 month?
200
The median overall survival of Zaltrap plus FOLFIRI
What is the 13.50 months
200
Person who played the Chief
Who is Edward Platt?
200
The dose of Zaltrap
What is 4 mg/kg
200
A cardiovascular condition that must be controlled if severe before Zaltrap may be resumed and dose reduced to 2 mg/kg
What is hypertension?
200
The dose of bev in the TML trial
What is 2.5 mg/kg per week (either 5mg/kg every two weeks or 7.5 every three weeks)?
300
The lead author of the VELOUR trail
Who is Van Cutsen?
300
The name of the agent that is a dog?
What is the agent K-13?
300
The dose of irinotecan used in the VELOUR trial
What is 180?
300
For recurrent proteinuria, suspend ZALTRAP until...
What is proteinuria is <2 grams/24 hours ?
(and then permanently reduce the dose of
ZALTRAP to 2 mg per kg)
300
The median OS in the for bev plus chemo in the TML trial
What is 11.2 months?
400
The relative risk reduction in death compared to FOLFIRI alone
What is 18%?
400
The name of Maxwell Smart's nemesis?
Who is Siegfried?
400
After the VELOUR trial, Zaltrap received this FDA review
What is Priority?
400
For minor surgery such as central venous access port placement, biopsy, and tooth extraction, ZALTRAP may be initiated/resumed
once........
What is the surgical wound is fully healed?
400
The primary endpoint in the TML trial
What is overall survival?
500
The hazard ratio (HR) for the placebo/irinotecan,
leucovorin and fluorouracil (FOLFIRI) group relative to the aflibercept/FOLFIRI
What is 0.81
500
The number of doors Maxwell Smart walks through to get the control (including phone booth)
What is 8?
500
The 4 S’s
What is Survival—18% relative risk reduction of death compared with FOLFIRI alone
Significant increase—in OS, PFS, and ORR
Separation of survival curves
Subgroup—OS in patients previously treated with bevacizumab and those not previously treated with bevacizumab
(subgroups were not powered to show statistical benefit)
500
A complete penetration of the wall of the stomach, small intestine or large bowel, resulting in intestinal contents flowing into the abdominal cavity.