Early Stage Disease
Maintenance Therapy
Herbs, Vitamins, Natural products
Imaging and Lung Cancer
Firsts
100
Number of cycles recommended for adjuvant chemotherapy.
What is 4?
100
Maintenance therapy in a 68 year-old adenocarcinoma patient after completing 4 cycles of carbo/paclitaxel/bevacizumab with partial response
What is bevacizumab?
100
Higher or lower: risk of developing lung cancer in patients with high beta-carotene intake.
What is higher?
100
Among chest X-ray, chest CT, and bronchoscopy, this has been shown in a randomized trial to improve lung cancer mortality as a screening test.
What is chest CT?
100
These institutions first published discovery sensitizing EGFR mutations.
What are DFCI and MGH, separately, in 2004?
200
Of 60, 80, or 100, the number of Gy used in SBRT to local lung lesions.
What is 100 Gy?
200
Recommended maintenance therapy in adenocarcinoma after 6 cycles of cisplatin plus pemetrexed.
What is pemetrexed?
200
Higher or lower: Risk of recurrence of resected lung cancer with the use of selenium (vs placebo)
What is a trend toward higher?
200
Recommended imaging workup for a patient with newly diagnosed small cell lung cancer.
What is CT chest with contrast, PET/CT and brain imaging (MRI preferred)?
200
He first identified EML4-alk translocations in lung cancer.
Who is Dr. Soda (Japan) in Nature, 2007?
300
Within 2 percentage points, the absolute improvement in 5 year survival with adjuvant chemotherapy.
What is 11%
300
Maintenance therapy after 6 cycles of carboplatin-paclitaxel in a patient with adenocarcinoma.
What is pemetrexed?
300
Chemotherapy initially derived from the bark of the pacific yew tree.
What is paclitaxel?
300
The negative predictive value of PET/CT for mediastinal nodal involvement.
What is 85-96%?
300
City where proton beams were first identified to be a potential anticancer therapy.
What is Cambridge, MA?
400
The surgical approach for a tumor invading a mainstem bronchus.
What is a sleeve resection?
400
Approved for use as maintenance therapy in a 58 year-old squamous cell carcinoma patient after 6 cycles of cisplatin plus gemcitabine?
What is erlotinib?
400
Chemotherapy based on a derivative from the bark of the tree Camptotheca acuminata.
What are topotecan and irinotecan?
400
Recommended followup and timing for a 47 year old non-smoking man who underwent chest CT after motor vehicle accident and was found to have a 5 mm RUL nodule.
What is a follow-up chest CT at 12 months?
400
He performed the first successful pneumonectomy for lung cancer.
Who is Evarts Graham, in 1933?
500
Per Intergroup 0139, the recommended therapy for stage IIIA disease that is potentially resectable by a lobectomy.
What is chemorads with EP50/50, followed by surgical resection and 2 additional cycles of EP?
500
Recommended maintenance after 4 cycles of carboplatin plus pemetrexed plus bevacizumab.
What is pemetrexed plus bevacizumab?
500
The mechanism of metabolism and excretion for St. John's Wort.
What is the cytochrome P450 (CYP3A4) system?
500
The recommended imaging follow-up for resected early stage lung cancer, per NCCN guidelines.
What is CT chest (+/- contrast) every 6-12 months for 2 years, then noncontrast chest CT annually thereafter.
500
They published the first study to link tobacco smoking to lung cancer.
Who are Ernst Wynder and Evarts Graham, in JAMA in 1950?