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PCNs
Cephalosporins
Tetracyclines
Macrolides
Aminoglycosides
100
Serves as a receptor for PCN
What is PCN-Binding protein?
100
Primary therapeutic use of the cephalosporins
What is treatment of gram-negative infections and for patients who cannot tolerate the less expensive PCNs
100
Tetracyclines act by
What is inhibiting bacterial protein synthesis?
100
Act by...
What is inhibiting protein synthesis by binding to the bacterial ribosome?
100
Bacteriocidal
What is act by inhibiting bacterial protein synthesis?
200
Bacteria most commonly affected by the PCNs
What is Gram-positive?
200
Classified by...
What is "generation"?
200
Tetracyclines which have longer durations of action and are permitted to enter the CSF
What is Doxycycline and minocycline?
200
Produce different effects at different dosage concentrations
What is bacteriostatic and bacteriosidal?
200
Occasionally given orally before intestinal surgery
What is for their local effect on the GI tract?
300
Rash, pruritus and fever
What is common sx of PCN allergy?
300
Third-generation cephalosporin with a broad spectrum of activity against gram-negative organisms
What is Cefotaxime?
300
Effective against a...
What is large number of different gram-negative and gram-positive organisms, and have one of the broadest spectrums of any class of antibiotics?
300
Common indications
What is whooping cough, Legionnaires' disease, infections by streptococcus, H. influenza, and Mycoplasma pneumonia?
300
Most frequent adverse effects
What is rash, n/v, fatigue?
400
Medication of choice for gonorrhea and syphilis caused by susceptible strains
What is Penicillin G?
400
Most common adverse effect of Cefotaxime
What is hypersensitivity?
400
Effective in the treatment of diseases such as...
What is Chlamydia, Rickettsiae, Mycoplasma and H. pylori?
400
Main application is for
What is patients who are unable to tolerate PCNs or who may have PCN-resistant infection?
400
Loss of hearing or balance
What is ototoxicity?
500
Portion of the chemical structure of PCN that is responsible for its antibacterial activity
What is beta-lactam ring?
500
Similar to PCNs, many cephalosporins
What is contain a beta-lactam ring?
500
Common adverse effects...
What is affect vaginal, intestinal and oral flora, as well as cause super infections?
500
Most severe adverse effect
What is hepatotoxicity?
500
of particular concern in patients with pre-existing kidney impairment
What is nephrotoxicity?