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Gnotobiotics
Equipment
Methodology
Axenic Animal Physiology
Deriving Axenic animals
100
Well known life is the study of animals whose micoflora is completely defined.
What is Gnotobiotics
100
A device that creates a barrier between animals and the outside environment.
What is isolator system?
100
The two broad areas of gnotobiotics in lab animal science.
What is the study of axenic animals and barrier housing techniques?
100
The life span of an axenic animal is this compared to non-axenic animals
What is longer life span?
100
This is the two ways that axenic animals are derived.
What is hysterectomy and embryo transfer?
200
An animal that is given a known group of bacteria or other organism to aid their digestive functions.
What is Define flora animal.
200
Isolators that are made of stainless steel or plexiglass
What is rigid isolators?
200
Research involves studies in nutrition, immunology and aging.
What is research using axenic animals?
200
Axenic animals are often characterized by this.
What is poor muscle development?
200
During this procedure embryos are collected, pooled, washed and surgically transferred into a pseudopregnant axenic female
What is embryo transfer?
300
Animals with normal flora but free of particular organisms.
What is specific pathogen free animals
300
Isolators made of a semi-rigid material that are much less expensive.
What is Flexible film isolators?
300
The process of getting rid of pathogens that results in high quality, disease free animals.
What is hysterectomy derivation or embryo transfer?
300
Axenic animals have a much larger organ than non-axenic animals
What is cecum?
300
Survival of pups during a hysterectomy rederivation is dramatically lower if perform more than this before normal birth.
What is more than 12 hours?
400
Dr. Philip Trexler
Who is the grandfather of modern gnotobiotic research.
400
A stainless steel container where materials/supplies are sterilized before being put in the isolator.
What is Supply cylinder
400
It makes an animal non-axenic and compromises research results.
What is the presence of microorganisms?
400
Axenic rats have these smaller organs than non-axenic rats.
What is hearts, livers and lungs?
400
Axenic foster mothers are chosen from strains that are naturally these 2 things.
What is naturally have large litters and good milk producers?
500
This allowed the vendors to rid their stocks of bacterial, viral and parasitological disease agents.
What is the advantage of gnotobiotics?
500
A flexible plastic tube of the same diameter as the entry port and the supply cylinder.
What is the transfer sleeve?
500
Without this, axenic animals would rapidly succumb to normally nonpathogenic microorganisms.
What is protective enviroments?
500
Axenic animals have different requirements than non-axenic animals
What is nutrient requirements?
500
When a axenic animal is given normal symbiotic (non-pathogenic) intestinal bacteria to normalize the gut.
What is a Schaedler cocktail?