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PI's
Misc
Integrase Inhibitors
Drug-Drug Interactions
Trials
100
I am the only protease inhibitor co-formulated with ritonavir
Lopinavir
100
As a class, these are the most common side effect of Protease (name 2)
What is GI upset (diarrhea) and dyslipidemia
100
I am the only Integrase Inhibitor that requires BID dosing in treatment naive patients
What is Raltegravir
100
I am a class of ARV that can decrease the level of most oral contraceptives by anywhere from 20-50% and am generally not recommended concurrently.
What are Protease Inhibitors
100
These trials confirmed the potency of Darunavir in treatment experienced patients
What are the POWER studies (1, 2 and 3)
200
I can cause hyperbilirubinemia with or without jaundice, but your ALT/AST will be just fine
Atazanavir
200
This trial showed that Darunavir had better virological response at 96 weeks and more favorable SE profile than Lopinavor, especially in patient with higher baseline viral load
What is the ARTEMIS trial
200
It is contraindicated to start me in patients with CrCl <70
What is Stribild
200
When I am prescribed to a patient taking Raltegravir, you should double their dose.
What is Rifampin, because I induce UGT leading to inc more rapid metabolism of raltegravir
200
In order to demonstrate their non-inferiority with regard to standard regimen at that time, Lopinavir and Fosemprenavir went up against which PI in 2002 and 2004 in the SOLO study.
What is Nelfinavir
300
I contain a sulfa-moiety so should be used in caution in patients with sulfa allergies, though usually they tolerate me.
What is Darunavir (also fosamprenavir)
300
Rifampin does this to the level of Protease Inhibitors
What is decreases. Current guidelines recommend avoiding concomitant use of rifampin with all protease inhibitors The use of rifabutin with a protease inhibitor typically causes a minor decreases in the protease inhibitor level. More importantly, rifabutin plasma levels increase significantly as a result of protease inhibitor inhibition of CYP450 enzymes
300
These studies showed that it can be dangerous to switch from PI based regimen to RAL if you dont know how effective the rest of your ARV cocktail is.
What are the Switchmark Trials 1 and 2
300
I am a statin that is metabolized primarily via glucoronidation and therefore am less effected by concomitant PI administration than other statins (that are primarily metabolized via CYP 3A4 and 2C9).
What is pitavistatin (also pravastatin)
300
This study showed that Atazanavir had similar virological efficacy as Lopinavir with better SE profile.
What is the CASTLE study
400
I can cause an increase in your PR interval leading to 2nd or 3rd degree heart block, I can also prolong your QT.
What is Lopinavir
400
This is required prior to starting Maraviroc
What is phenotypic tropism assay
400
I am the integrase inhibitor you must take with food
What is Elvetegravir
400
These two classes of ARV do not effect methadone levels
What are CCR5 inhibitors and Integrase inhibitors. NRTIs have effect on methadone level but not clinically significant to require alteration in dosing.
400
This trial demonstrated that Dolutegravir was non-inferior to Raltegravir in treatment Naive patients
What is the Spring 2 Study
500
PPI's and H2 blockers decrease my absorption because I need an acidic environment.
Atazanavir
500
These may bind integrase inhibitors and decrease absorption, therefore they should be taken at least 2hr before or 6hr after the integrase inhibitor
What are polyvalent cations (aluminum, magnesium, etc) containing products such as antacids and laxatives.
500
We both inhibit tubular secretion of creatinine and thus cause increase in creatinine without effecting the GFR
What are Dolutegravir and Cobicistat
500
Rifampin, and to a lesser extent rifabutin, can induce this enzyme and thus impact raltegravir and dolutegravir level
What is UGT1A1 enzymes (uridine diphosphate glucuronosyltransferase)
500
This trial led the FDA to approve Dolutegravir BID for treatment of patients with virus resistant to RAL and EVG
What is the Viking Trial