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Misc
Misc
Misc
Misc
Numbers
100
What are the 2 main types of Breast Cancer
Ductal Lobular
100
What is the difference between a lumpectomy, mastectomy, and radical mastectomy (obsolete)
Answer
100
At what age and how often should Mammography be done for the general population
From age 50-74 Every 2years
100
What lifestyle changes can one make to decrease the risk of Breast Cancer
Limit Alcohol use Have Kids and Breastfeed No smoking Be physically active
100
How many times more common is Breast Cancer in Women than men
100X
200
What lymph nodes do you examine in a Breast Cancer patient?
Axillary Supraclavicular Infraclavicular
200
What are the diagnostic/screening tests for Breast Cancer
Breast Self Exam Mammogram Ultrasound MRI Fine Needle Aspiration Biopsy
200
What drug is used for HER2 +ve Breast Cancer
Herceptin (Transtuzumab)
200
What major factors determine Breast Cancer prognosis
TNM StagingGrading Bloom Richardson Scale Receptor Status
200
What % of Breast Cancer are due to BRCA1/2
2-3%
300
What are 5 signs/symptoms of Breast Cancer
Lump Change in Breast size/shape Skin Dimpling Nipple Inversion Nipple Discharge Inflammation- redness, swelling, pain
300
What does BIRADS stand for
Breast Imaging Reporting and Data System
300
Which gives a better prognosis: Radiation of the breast during the operation, or Post-Op radiation of the Breast
No Diff
300
What has better Prognosis: Estrogen +ve Progesterone +ve HER2 –ve Estrogen +ve Progesterone +ve HER2 +ve
Estrogen +ve Progesterone +ve HER2 –ve
300
If someone is BRCA1/2 Positive how likely are they to get Breast Cancer
60-85%
400
What are 5 causes/risk factors of Breast Cancer
Excessive Estrogen- Early puberty; late menopause, nulliparity, not breastfeeding Older Age Female Alcohol Smoking Iodine Deficiency Obesity Family History Previous Breast cancer in other breast
400
What drug is used for Estrogen +ve Progesterone +ve Breast Cancers and what is the most common side effect of this drug
Tamoxifen DVT
400
How is the PI3K/AKT and RAS/MEK/ERK pathways related to breast cancer
These pathways prevent cell suicide. They become overactive in Breast Cancer
400
Who has better prognosis: A young girl with breast cancer or a postmenopausal lady with breast cancer
postmenopausal lady with breast cancer
400
What is the most common type of cancer in Females What is the most deadly cancer in Females What is the lifetime risk for a healthy female to have Breast Cancer
Skin Lung 12.5%
500
What four arteries supply the breast
Internal Mamillary Artery (Internal Thoracic) Intercostal Arteries Thoracoacromial Artery Lateral Thoracic Artery
500
Explain the different BIRADS scores
Scale out of 6 points 1= good prognosis, 6=bad prognosis 0 Incomplete 1 Negative 2 Benign 3 Probably Benign 4 Suspicious of Cancer 5 Highly suspicious of Cancer 6 Proven Cancer
500
What are the 3 common Chemo Drugs for Breast Cancer
Cyclophosphamide Doxorubicin Docetaxol
500
What is the TNM Staging for Breast Cancer
TO= <2cm T1= 2-5cm T2= >5cm T3= extends to chest wall NO= no palpable nodes N1= palpable nodes discrete N2= palpable nodes matted MO= no metastasis M1= metastasis
500
What is the Bloom Richardson Scale and explain the grading
Scale out of 9 points 1= good prognosis, 9=bad prognosis Tubule Formation: 1= tubules in >75% tumor 2= tubules in 10-75% tumor 3= tubules in <10% tumor Nuclear Pleomorphism: 1=nuclei w/ minimal variation in shape/size 2=nuclei w/ moderate variation in shape/size 3=nuclei w/ severe variation in shape/size Mitotic Count 1=little mitosis 2=moderate mitosis 3=severe mitosis