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Gene Therapy

100

What is Gene therapy ?

It is a new technique that is used to fix gene disease, changing abnormal genes to normal ones.

200

Name at least 2 techniques used for Gene Therapy.

A normal gene may be inserted into a nonspecific location within the genome to replace a nonfunctional gene. This approach is most common. An abnormal gene could be swapped for a normal gene through homologous recombination. The abnormal gene could be repaired through selective reverse mutation, which returns the gene to its normal function. The regulation of a particular gene could be altered.

300

Name 3 types of viruses used for Gene Therapy.

Adenoviruses Retroviruses Herpes simplex virus

400

What is a vector ?

It is a type of virus inserted into the body, to cure disease.

Pros & Cons

100

Name 2 disadvantage of gene therapy.

It is very expensive. It is still developing, any error in finding the precise location of the defected gene, could cause a risk of new disease.

200

Name 2 advantages of Gene Therapy

It can wipe out genetic disease. Eliminate suffering for future generations.

300

Name at least 2 of the 4 things that stops Gene therapy from being effective.

Short-lived nature of gene therapy Immune response Problems with viral vectors Multigene disorders

400

Is it possible that a superior race can be formed ?

Some people are concerned that gene therapy will be used to create a superior race. This is not the goal of the geneticist.

History

100

When did Gene Therapy research began ?

They began researching in 1972 .

200

What is the name of the institution that was first successful in Gene Therapy ? Hint: NIH

National Institute of Health

300

Fill in the blank: In 2011 a man was cured of _____using gene therapy.

HIV

400

Which journal reported that researchers succeeded at halting ALD ?

Science Journal