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Aloxi PI
Gralla
Eisenberg
Aapro
Potpouri
100
Aloxi's dose adjustment for Hepatic impairment
What is not necessary in patients with any degree of hepatic impairment
100
What two drugs did Gralla compare and at what strengths?
What is Aloxi .25 vs Ondansetron (Zofran)32mg.
100
What two drugs did Eisenberg compare?
What are Aloxi .25 and Delasetron (Anzemet) 100mg
100
Primary endpoint for Aapro
What is CR during Acute Phase in HEC (0-24 hours)
100
What is aloxi marketed for and what form does it come in?
What is CINV and IV infusion
200
dose of aloxi
What is a single 0.25 mg IV dose administered over 30 seconds - dosing should occur approx 30 minutes before the start of Chemo.
200
Journal name and year for Gralla study
What is Annals of Oncology 2003
200
The mean age for both groups in the trial?
What was 53 years old
200
Journal name and year Aapro was published
What is Annals of Oncology 2006
200
Headache
What was the most frequent AE in all Trials
300
Contraindications for Aloxi
What are patients known to have hypersensitivity to the drug or any of it's components.
300
Name three Chemo regimines included in Gralla
What are any of the following: Carbo,Epirubicin,Idarubcin, Ifosfamide, Irinotecan, Motxantrone, Mehtotrexate,Cyclophos,Doxi, Cisplat.
300
Primary endpoint of Eisenberg
What was CR during acute phase following MEC administration.
300
What does the name AAPRO stand?
What is Last name of key investigator, MS Aapro
300
Name 2 Hospital GPO's and 2 Clinic GPO's and 2 Wholesalers
Hospital: Novation, Premier, Med Assets, Clinic : Onmark, ION, USO Wholesalers: Amerisource Bergen, Mckesson,
400
List the Aloxi pediatric dose and pregnancy category.
What is dose below 18 yrs has not been established and Pregnancy Category B (should be used in pregnancy only of clearly needed.)
400
What were the study results (CR's) for Acute Delayed and Overall for Aloxi vs Ondansetron?
What are: Acute: Aloxi Ondansetron 81 69% Delayed 74 55% Overall 69% 50%
400
How many patients were in the trial
What is 569 total (Initially, 592 only 583 were treated but 14 patients were excluded from the analysis).
400
List the CR's for both Aloxi and Ondansetron
What is Aloxi 59% Cr vs Ondansetron 57.
400
Name Eisai's partner on Aloxi and country headquarters is located in?
What is Helsynn and Switzerland
500
Complete indication for Aloxi word for word
What is Aloxi is a subtype 3 5HT3 receptor antagonist indicated for Moderately emetogenic cancer chemo - prevention of acute and delayed nausea and vomiting associated with initial and repeat courses. Highly emetogenic cancer chemo - prevention of acute nausea and vomiting associated with initial and repeat courses.
500
Name the primary endpoint of the Gralla study and two of the six Secondary Endpoints
What is Primary: CR during Acute phase: 0-24 hours following MEC. Secondary : Any two of the following: CR during delayed phase 24-120 , Number of emetic episodes, TTF, Severity of Nausea, Patient global satisfaction or QOL as measured using a modified FLIE questionnaire.
500
What % of patients in the trial were breast cancer?
What is 64%
500
List the three most common cancer types in Aapro and the two most common HEC agents
What are Ovarian, Lung, and Hodgkins Lymphoma What are High dose cysplatin and Cyclophosamide
500
What are the names of the three current Aloxi contracts?
What APP, CCG, and TPP