Types of Tubes
This type of enteral tube enters through the mouth and ends in the stomach and is considered an option for short term use
What is Orogastric?
____-bore tubes are commonly used for EN feedings and medication administration and are generally more comfortable for patients
Current enteral nutrition formulas have been reformulated to contain much lower amounts of this vitamin to help reduce the risk of interaction with warfarin
This term refers to the proportion of a drug dose that reaches systemic circulation and depends on the fraction of drug absorbed from the gut, the fraction removed by efflux transporters, and/or enzymatic metabolism at the gut mucosa
What is bioavailability?
The primary site of action for drugs such as sucralfate and antacids is in this organ and provide little value when administered via small bowel tubes
What is the stomach?
This type of enteral tube enters the body from the lower abdomen and ends in the jejunum
What is jejunostomy?
This type of enteral tube access is generally preferred for medication administration
When administered concurrently with enteral nutrition, phenytoin's absorption may be ______ by up to 70%
What is reduced?
This term refers the ability of a drug molecule to cross the apical membrane of the enterocyte and depends on drug specific factors such as particle size, solubility, and lipophilicity
What is absorption?
This DOAC can be given via G-tube but not via J-tube
What is rivaroxaban?
This type of tube access is preferred for patients with pancreatitis, gastroparesis, severe GERD, or with increased aspiration risk
What is small bowel (jejunal)?
This type of medication formulation is preferred for enteral tube administration as long as it is tolerable
What is liquid?
This should be interrupted or held to allow for medication administration via enteral tubes to prevent interactions with the medication
What is enteral nutrition?
These two properties are determinants of drug bioavailability
What are solubility and permeability?
This fluoroquinolone's suspension formulation should not be given via feeding tube because it may adhere to the tube and cause tube occlusion
What is ciprofloxacin?
Three types of enteral tubes that can enter through the nasal passages
What are nasogastric, nasoduodenal, or nasojejunal?
This should be done to an enteral tube that is being used for gastric suctioning prior to and for at least 30 minutes after medication administration
What is clamping?
This medication for parkinson's disease should be separated from EN or protein administration by at least 2 hours
What is carbidopa-levodopa
This term refers to a medications ability to dissolve in solution and is determined by many factors including melting point, lipophilicity, drug shape, gut pH, and gut motility
What is solubility?
This medication can be used as an alternative for tamsulosin to allow for enteral tube administration
What is silodosin?
This type of feeding strategy closely mimics a normal eating pattern and is commonly used with tube access that ends in the stomach, however, is not generally tolerated in patients with small bowel tubes
What is bolus feeding?
This should be done between administrations of medications via enteral tubes to prevent medication interaction and reduce the risk of tube occlusion
What is water flushes (5-10 mL)?
This drug vehicle can be used to prevent drug degradation from stomach acid for acid liable medications or can be used to activate medications that require an alkaline pH
What is sodium bicarbonate?
This term describes the fraction of a drug absorbed across the apical membrane of the gut epithelium and is determined by many factors such as the drug's affinity for transporters, the partition coefficient, and the thickness of the gut's membrane
What is permeability?
This class of medications commonly are formulated as enteric coated tablets or delayed-release capsules because they are acid liable (inactivated by gastric acid), which presents extra challenges when administering them via gastric tubes. Additionally, their suspension formulations are high risk for causing tube occlusions
What are proton-pump inhibitors?