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Questions 5
100
MMN Neuropsych Disorders? 

Parkinsons, Alzheimer's, Schizophrenia, Tinnitus, Alcoholism, Brain injury, Social withdrawal

100

MMN auditory/language disorders?

Prematurity, Aphasia, Non-native language learning, Dyslexia, Adhd, Peripheral auditory dysfunction, Autism, Ampllification 

100

Why is the MMN of interest? 

  • It is independent of conscious attention to auditory stimuli
  • It can be elicited by stimuli that differ in very fine ways

 

 

100

List the 3 analysis techniques for MMN? 

Area under curve, integrated MMN analysis, Principal component analysis

100

Fill in the blank: 

P300: Low ISI, _______ rate, creates low amp with ______ differences 

Faster

Duration

200

Fill in the blank: 

P300: As age increases, latency _______ (about _____ per year) 

MMN: As age increases, latency ______ (about _____ per year)


Decreases

19ms

Decreases

11ms

200

What is: 

  • A time frame (200ms) that shifts backward & forward in time (during which auditory info is integrated)

 

Temporal window of integration

200

What is: 

  • Differences in multiple parameters between standard & target stimuli
  • MMN amplitudes are larger with more complexity

 

Complexity

200

What is: 

  • Time interval between onset of 2 adjacent stimuli
  • Similar to ISI
  • Inversely related to stimulus rate

 

Stimulus onset asynchrony

200

List the uses for the P300? 

Alcoholism, Depression, Autism, Dementia, Schizophrenia, Epilepsy, Adhd, TBI

300
How can we differentiate the MMN from N1? 
  • MMN will be elicited by any change b/w standard & deviant stimulus
  • MMN is unaffected by ISI
  • MMN can be evoked by fine differences in stimulus characteristics
  • MMN latency is related to differences b/w standard & deviant stimuli
  • Imaging techniques have found differences in generator sites b/w the N1 and MMN
300

How is the MMN derived? 

  • Subtract standard stimuli evoked response from target stimuli evoked response
  • Each waveform is collected & analyzed separately

 

300

Explain Integrated MMN analysis?

  • Amp integrated over time window
  • Analysis occurs for both standard & target
  • Statistical comparison between integrated waveforms & single sweep standard responses
300

Explain derivation of the MMN? 

  • Subtract standard stimuli evoked response from target stimuli evoked response
  • Each waveform is collected & analyzed separately
300

Explain Principal component analysis? 

  • Similar to other AEP analyses
  • Locate wave components that best identify the variances b/w the waves OR the most consistent response
400

List 5 MMN stimulus types? 

Duration, Musical chords, Intensity diffs, Frequency diffs, gaps with tonal/noise stimulus

400

List challenges with MMN analysis? 

  • Response is relatively small (1-2uv)
  • Derivation of waveform introduces noise
  • No distinct peaks/troughs
  • Amplitude is not constant
  • Response reliability is low

 

400

How do we analyze the P300 latency? 

  • it occurs between 250-400ms (up to 800ms in infants)
  • pick a peak: find midpoint between when initial part of wave crosses baseline & when trailing part crosses baseline


400

How do we analyze the P300 amplitude? 

  • Ranges between 10-20 uv
  • Peak to peak: from P300 to trough right before or after
  • Baseline to peak: requires stable prestimulus baseline

 

400

Explain how to use tones for P300? 

  • Standard of 1k Hz and a target of 2k Hz
  • Amplitude of P300 increases with differences between F1 and F2 (the more different the tones, the better… 500 and 2000)
  • Might not work with persons with HL

 

500

What is the single stimulus paradigm? 

  • Using a single auditory stimulus (standard) and using a pause
  • Amplitude is typically smaller than normal
  • Used for cognitive impaired
500

What is the multiple stimulus paradigm? 

  • Using 2 standards and 1 target
  • 1 standard has lesser probability than the other
  • Reflects “automatic cognitive processes”
  • Uses a distractor signal (dog barking)


500

What is the MMN? Explain in detail: 

  • A derived negative wave component that occurs between 100-250ms (post stimulus).
  • It is an event-related potential, a cognitive evoked response, and has a small amplitude.
  • It is a preconscious or pre-perceptual detection of an auditory change
500

What is the P300? Explain in detail

  • A complex that may occur as late as 600ms with some speech signals.
  • It is endogenous (originates from within)
  • Obtained by giving the patient a task to attend to stimulus
  • Can be collected passively
  • Uses the oddball paradigm

 

500

Why do we use EABR? Explain it. 

A near-field recording that sends electrical stimulation directly to the cochlea. This prevents a traveling wave, so we get a more direct response. It is usually used for CI candidacy. Latency is about 20ms later and typically we do not see wave I.