Biomodal Basics
This company enables simultaneous sequencing of genetic and epigenetic information from a single sample.
What is Biomodal?
Biomodal’s platform avoids this harsh chemical traditionally used in methylation sequencing.
What is bisulfite?
Multiomics refers to the integration of multiple layers of biological data, such as genomics and this.
What is epigenomics?
Epigenetics refers to changes in gene activity that do not involve changes to this.
What is the DNA sequence?
duet evoC enables simultaneous detection of genetic and epigenetic information from this small amount of DNA.
what is 5ng
Biomodal’s platform distinguishes between canonical bases and these two modified cytosines.
What are 5mC and 5hmC?
Biomodal’s platform is compatible with this type of library preparation.
What is standard Illumina library prep?
This modified base is often associated with gene activation
What is 5hmC?
5mC is typically found in these regions and is associated with transcriptional repression.
What are gene promoters?
The duet platform suppresses errors from these two common sources in sequencing.
What are PCR and sequencing errors?
Biomodal’s technology captures this version of the genome.
What is the 6-base genome?
Biomodal’s platform can be used with this type of sequencing read length.
What is short-read?
This modified base is often associated with with gene repression
5mc
5hmC is especially abundant in this organ, suggesting a role in neurodevelopment.
What is the brain?
Unlike traditional methylation analysis, duet evoC does not require this harsh chemical treatment.
What is bisulfite conversion?
The name of Biomodal’s flagship multiomics solution.
What is duet or evoC
Biomodal’s platform uses this type of chemistry to detect modified cytosines
What is enzymatic conversion?
Biomodal’s duet platform combines genetic and epigenetic analysis in this number of workflows
what is a single workflow?
Biomodal’s technology distinguishes 5mC and 5hmC using this type of sequencing resolution.
What is single-base resolution?
duet evoC data can be used to build predictive models of these two key biological processes.
What are gene expression and chromatin accessibility?
Biomodal’s technology helps researchers study this process that modifies gene expression without changing DNA sequence.
What is DNA methylation?
Biomodal’s platform can be used to study this type of cytosine modification often found in brain tissue.
What is 5hmC?
The duet evoc assay uses this structure to tether original and copy DNA strands.
What is a hairpin structure/adapter?
his feature of duet evoC data links genetic variants directly to methylation variation.
What is variant-associated methylation (VAM)?
This new analysis software from Biomodal reveals tissue-specific methylation patterns across human organs.
What is modality XPLR?