Epilepsy Overview
This chronic neurological disease is caused by the abnormal discharge of brain neurons.
What is epilepsy?
This molecule serves as the essential energy-supplying molecule for all living cells.
What is ATP?
This type of transgenic mouse was used specifically to study neuronal energy molecules.
What is Thy1-ATeam?
These are the four categories into which epilepsy is divided.
What are Focal, Generalized, Combined Generalized and Focal, and Unknown?
In astrocytes, glucose from the blood is converted into this molecule, which then produces NADH to generate ATP.
What is pyruvate?
This substance was used by researchers to visualize local blood brain volume dynamics.
What is Texas Red dextran?
This diet, where the body uses fat instead of glucose as an energy source, is used as a treatment for epilepsy
What is the ketogenic diet?
This specific cellular component consumes a significant amount of ATP to pump sodium out and potassium back into the neuron.
What is the sodium-potassium pump?
Researchers compared rodent EEG patterns known as this to patterns seen in human epilepsy patients.
What is after-discharge (AD)?
These three specific factors are listed as the etiology (causes) of epilepsy.
What are genetics, acquired brain injuries, and infection (or metabolic/immune disorders)?
These cells contact both blood vessels and neurons to help manage energy dynamics.
What are astrocytes?
To detect energy changes, researchers used these two specific wavelengths of excitation light.
What are blue (~440 nm) and teal (~510 nm)?
Roughly this percentage of epilepsy patients display resistance to Anti-Epileptic Drugs (AEDs).
What is 30%?
This happens to ATP levels in the brain in response to epilepsy.
What is they decrease?
This experimental process involves repeated electrical stimulation to increase the duration of epileptic reactions.
What is kindling?