Kidney Anatomy
Normal Functions
ESKD Basics
Homeostais Disrupted
Clinical Signs
100

These two bean-shaped organs sit on either side of the spine in the posterior abdomen.

What are the kidneys?

100

The kidneys receive this percentage of the body's total cardiac output.

What is 20%?

100

This abbreviation stands for the final and most severe stage of chronic kidney disease.

What is ESKD?

100

Sodium and water retention in ESKD causes this visible swelling of body tissues.


What is edema?

100

This most common ESKD symptom is caused by anemia and toxin buildup.

What is fatigue?

200

This outer region of the kidney surrounds the inner region, known as the medulla.

What is the cortex?

200

The kidneys produce this hormone, which stimulates red blood cell production.

What is erythropoietin?

200

In ESKD, the GFR falls below this number in mL/min.

What is 15 mL/min?

200

This electrolyte imbalance — elevated potassium — puts ESKD patients at risk for dangerous arrhythmias.

What is hyperkalemia?

200

Uremic toxins building up in the blood cause this maddening skin symptom

What is itching (pruritus)?

300

This narrow tube carries urine from the kidney to the bladder for storage.

What is the ureter?

300

The kidneys activate this vitamin, which is essential for bone health

What is Vitamin D?

300

This dangerous condition occurs when waste products accumulate in the blood."

What is uremia?

300

The retention of hydrogen ions (H+) in ESKD leads to this acid-base imbalance

What is metabolic acidosis?

300

This respiratory symptom results from fluid overload and pulmonary congestionffect brain

What is shortness of breath?

400

This is the functional unit of the kidney, where filtration and reabsorption take place.

What is the nephron?

400

By regulating sodium, potassium, and fluid levels, the kidneys help maintain this

What is homeostasis?

400

In ESKD, the kidneys lose their ability to maintain this — the body's internal chemical balance.

What is homeostasis?

400

The drop in erythropoietin production in ESKD directly causes this blood condition.

What is anemia?

400

When toxins accumulate and affect brain function, patients experience this neurological symptom

What is confusion?

500

Filtration in the nephron begins at this structure

What is the glomerulus?

500

Filtered fluid travels from the proximal tubule → Loop of Henle → this structure before becoming urine

What is the distal tubule?

500

ESKD usually requires this intervention to replace lost kidney filtration function

What is dialysis?

500

Fluid backup from sodium and water retention in ESKD can cause this life-threatening lung complication.

What is pulmonary edema?

500

This muscular symptom is caused directly by electrolyte disturbances — particularly potassium and calcium

What are muscle cramps?