Toxicology
Which heavy metal poisoning presents with signs of catecholamine excess, neuropsychiatric symptoms, and rash?
Chronic Mercury toxicity
What Sympathetic receptor contracts smooth muscle/
Alpha 1
What type of drug is Oxaprozin and what is its clinical use?
NSAID (propionic acids)
Fever, Pain, and Inflammation
What is defined as pain greater than 3 months following resolution of erythematous vesicular rash and blisters in dermatome distributions T3 - L3 (can also get along cranial distribution)
Posthepatic Neuralgia
What to substances can be used to measure ECF?
Inulin and Mannitol
What is the likely diagnosis in a patient that presents with progressive worsening peripheral neuropathy? Physical exam reveals areas of hyper- and hypopigmentation, as well as hyperkeratosis. LFTs are also elevated with pancytopenia. The patient restores antique furniture as a hobby
Arsenic Poisoning
Stimulation of Beta 2 receptor causes what effect on the body?
Relaxation of smooth muscle (Bronchiodilation/relaxation)
1. Heart Failure
2. Cardiogenic Shock
3. Septic Shock
What kind of pain is caused by injury to body tissues?
Nociceptive Pain
If I have a small lipid drug, will is have a high or low Volume of Distribution?
High
What are the 4 antidotes can be used to treat heavy metal poisoning?
1. CaNa2EDTA
2. Dimercaprol
3. Penicillamine
4. Succimer (children)
M2
What partial Mu agonist is used to attenuate opioid withdrawal symptoms?
Buprenorphine
What type of pain is physical pain that is caused, increased, or prolonged by mental, emotional, or behavioral factors, without evidence of physical injury or illness?
Psychogenic Pain
What is the formula used to calculate loading dose?
LD = (DC * Vd)/ F
LD = loading dose
DC= drug concetration
vd= volume of distribution
F = Bioavailablity
What is the Toxic mechanism and effect of Acetaminophen?
Mechanism: Covalent Bonding
Effect: Hepatic Necrosis
Stimulation what what Autonomic system and receptor causes increased Renin secretions?
Sympathetic
Beta 1 receptor
What is the clinical use of Gabapentin?
1. Seizures
2. Neuropathic pain
What type of pain results from a stimulus that is usually harmless?
Allodynia
What is the formula use to calculate Maintenance Dose?
MD = (DC*CL)/F
MD= maintenance dose
DC = drug concentration
CL = Clearance
F = Bioavailability
What three drugs Enhance the metabolism of Digitoxin?
Phenobarbital
Phenytoin
Rifampin
What Autonomic system, neurotransmitter, and receptor innervates the sweat glands?
Sympathetic
ACh
Muscarinic receptors
A patient was accidentally exposed to Parathion, what medication can we give this patient ? (can have 2 answers)
1. Atropine
2. Pralidoxime
What type of pain is an exaggerated pain response to noxious stimulus?
Hyperalgesia
What is the formula used to calculate Volume of Distribution?
VD = TBD/PC
VD = volume of distribution
TBD = Total body Dose
PC = measure plasma concentration