Major Depressive Disorder
An abbreviated pneumonic to remember the clinical features of depression
What is SIG E CAPS
The number for the Suicide and Crisis Lifeline
What is 988
An SSRI with the longest half-life and lowest risk of discontinuation syndrome with abrupt cessation
What is fluoxetine
A GABA-A agonist administered over a 60-hour infusion in a REMS licensed healthcare facility
What is brexanolone
Aged cheeses, aged meats, tap beers
What are examples of tyramine-containing foods
SSRIs, SNRIs, mirtazapine, bupropion, and vortioxetine
What are first line antidepressants for MDD
Access to firearms, family history of completed suicide, social isolation
What are risk factors for completed suicide
A racemic SSRI that poses a higher risk of QTc prolongation and should be used with caution in elderly patients
What is citalopram
What are MAOIs
A rare complication suspected when using multiple serotonergic agents that in severe cases may lead to life-threatening hyperthermia
What is serotonin syndrome
A self administered MDD rating scale that is commonly used in clinical practice to monitor symptom severity and assess the need for treatment
What is Patient Health Questionnaire (PHQ-9)
Increased risk of suicidal thinking and behavior in children, adolescents, and young adults (18-24) with MDD or other psychiatric disorders
What is the BBW of all antidepressants
A fist-line antidepressant with the lowest risk of sexual dysfunction
What is bupropion
A first line antidepressant class for both permpartum depression and pre-menstrual dysphoric disorder
What are SSRIs
S-enatiomer of an aesthetic that can be administered intranasally for treatment-resistant depression
What is esketamine (Spravato)
Duration of an adequate trial of an antidepressant
What is 4-6 weeks
Class of antidepressants most likely to be fatal if taken as an overdose
What are tricyclic antidepressants (TCAs)
A duration 4-5 times the half life where no serotonergic agents are used to minimize the risk of serotonin syndrome when using irreversible inhibitors
What is an MAOI washout period
The dose of zuranolone in a patient with CKD and an eGFR of 32 ml/min
Non-pharmacotherapy involving seizure induction that is 80-90% effective in treating MDD
What is electroconvulsive therapy
Carvedilol, levetiracetam, clonazepam
What are medications that may impact mood/worsen mood
Rating scale for suicidality that can be helpful in assessing if immediate intervention is needed to prevent suicide
What is the Columbia-Suicide Severity Rating Scale (C-SSRS)
A first-line antidepressant that should be avoided for patients with hepatic impairment
What is paroxetine
The type of providers prescribing the majority of psychiatric medications
Who are Primary care physicians (PCP)