B cells
What are the different types of naïve mature B cells?
What are B1, B2, and Marginal Zone B cells
Does the heavy or light chain of antibodies have a D segment?
What is heavy chain?
What is the location where gene rearrangement take place for T cells?
What is the thymus?
What do we call the group of closely-related versions of a virus (such as DENV1-4)?
What is a serotype
What family of cytokines is characterized by the presence of a four-helix bundle motif in its structure?
What are Hematopoietin (Class I) Cytokines?
What is the difference between TI-1 Ag and TI-2 Ag?
TI-1 Ag requires an extra activation signal, so the BCR binds to the Ag and PRR (TLR4/LPS). TI-2 Ag has cross-linking occurs so multiple BCRs bind and have extended activation signal.
What enzyme is responsible for isotype switching?
What is AID?
MHC Class II binds to which T-cell coreceptor?
What is CD4?
A patient with a previous infection to DENV3 and then gets infected with DENV2. What will be the key clinical outcome as a result?
What is antibody-dependent enhancement (because of infection with different serotypes)
Which Interferon type is produced by cells associated with the adaptive immune system?
What is type II?
What type of B cell cancer impacts the lymph nodes and spleen?
What are B-cell lymphomas?
Name the isotype that is protease resistant, and describe its location and at least one of its effector functions
What is IgA; Found in mucosa of the gut, reproductive tract, and lungs as well as fluid secretions; Effective at neutralizing toxins and pathogens (little opsonization and complement)
Describe the 2 process that occur during thymic selection
Positive Selection-If TCR binds to MHC/Ag with low affinity, they survive
Negative selection- High binding to MHC/Ag=death by apoptosis, No binding to MHC/Ag=death by neglect
Depletion of cross-reactive antibodies from DENV-immune sera was performed using this method, confirming the role of specific antibody populations in ADE.
What is virus-specific depletion using a heterotypic virus?
The Epstein-Barr Virus's capability to have a protein that mimics IL-10 is an example of a ...
What is acting as a pathogen-derived cytokine antagonist?
What word is used to describe the signaling during the T2 positive selection stage of peripheral tolerance?
What is tonic signaling?
What type of immunoglobulin is the first response to antigen?
What is IgM?
Which cDNA clones were identified as T-Cell Specific After the Subtractive Hybridization Experiment?
What are TM90 and TM86?
What is the phenomenon in which non-neutralizing antibodies enhance the infection of a virus, increasing the risk of severe disease in individuals exposed to a different serotype?
What is ADE?
What are the polarizing cytokines for T-Regulatory Cells?
What are IL-2 and TGF-β?
During V(D)J recombination, which enzyme is used to open up the hairpin structure?
What is Artemis?
What are the two important enzymes that are knocked out in a SCID mouse?
What are RAG1 and Ku70?
What transcription factor is especially active during the Single Positive stage?
What is AIRE transcription factor?
What is the purpose for which competition ADE assays were used in this paper?
What is to research the virion protein prM, as it was difficult to make a recombinant version of it?
A patient is experiencing a condition consisting of an exacerbated immune response. The doctor concludes that it stems from the patient immune system's failure to immunosuppress itself. Which family of cytokines should the doctor look into?
What are Interferons (recall IL-10 is a part of IFN-gamma family)?