Staphylococcus
impair neutrophil and T-cell recruitment
What is Extracellular Adherence Protein (Eap)?
surface protein with polar distribution is key for cell-to-cell spread-promotes actin polymerization
What is ActA?
Intracellular spore-like form that divides within membrane bound inclusion and can’t survive outside a cell.
What is a Reticulate body?
Different antigens are expressed by the bacteria expressed in tick versus mammal. OspA(INCREASED) OspC(DECREASED) is for this organism
What are Ticks?
0-3 of a certain protein can be expressed by a single strain and functions in close attachment to host cells. It can also undergo phaser and antigenic variations based on enviroment.
What is Opa (OMPII)?
polymer protects against antimicrobial peptides and neutrophil phagocytosis
What are Poly-Gamma-Glutamate (PGA)?
Enzymes that allow the release of bacteria from a phagosome
What are phospholipases?
This disease is Transmitted by bite from ticks, and Attaches and invade vascular endothelial cells resulting in Fever, muscle pain, severe headache, nausea and vomiting
What is Rickettsia rickettsii?
genes are located on a linear plasmid in a silent state, and sequences are recombined into an expression site on another plasmid.
What is Vlp and vsp?
Symptoms: lower abdominal pain, abnormal menses Can result in inflammation of fallopian tube, with scarring Important cause of infertility, ectopic pregnancy
What is Salpingitis?
Cell-to-cell communication - population density-dependent and environmental-dependent gene regulation - regulates virulence factor production and biofilm formation
What is quorum sensing?
This internalins binds HGFR [hepatocyte growth factor receptor]
What is InlB?
A range of serovars resulting in Urethritis/Cervicitis, Perinatal infections, Inclusion conjunctivitis
What is D-K?
When louse-borne this disease is spread person to person if the parasite is crushed causing a repeating period of high internal body temperature(40 C) due to new variants
What is relapsing fever?
Similar to other outer membrane component of bacteria this fatty sugar is unique to neisseria and plays a major role in production of inflammatory mediators
What is LOS?
Degrade host cell components to promote spreading of the pathogen within the host
What are Exoenzymes such as Hyaluronidase?
This enterotoxin is acid-tolerant, proteolysis-resistant toxin that can cause emetic illness, i.e., vomiting - circular peptide, cereulide, with ionophore activity
What is heat-stable?
A LGV stage results in a small ulcer on genital mucosa or adjacent skin
What is the primary stage?
Accounts for development of secondary stage, lifetime persistence by segmental gene conversion
What is Antigenic Variation of TprK?
This disease shows brupt onset of illness: spiking fever, chills, arthralgias ,myalgias and 75% of people develop petechial rash.
What is Meningococcemia?
Virulence factor that Lyses neutrophils and macrophages
What is Panton-Valentine Leukocidin?
A type of effect that is caused by toxin production which results in myocarditis; significant cardiomyopathy: enlargement, arrhythmia, pump dysfunction, shortness of breath and paralysis of soft palate and select muscle groups, most seriously the diaphragm
What are systematic effects?
Secreted by Chlamydia in order to keep host cells alive until RBs mature into EBs
What are Anti-apoptotic factors?
While penicilllin is first used to treat syphilis today this antibacterial drug that targets bacterial ribsomes shows hgih resistance among circulating strains.
What are Macrolides?
Capsule expression is down-regulated in this period in N. meningitidis
What is carriage?