Tumor Immunology
Network of proteins, cells, tissues, and organs which can provide protection against bacteria, viruses, and cancer
Immune System
Process by which cancer cells spread from the primary tumor to other parts of the body
Metastasis
Formation of blood vessels from an existing architecture
Angiogenesis
Tumor Microenvironment
The federal law that ensures the humane treatment of animals in research facilities
Animal Welfare Act
Activation of the immune system
Immune Response
A barrier that must be crossed for cancer invasion and metastasis
Extracellular Matrix (ECM)
Takes place during embryogenesis, wound healing and metastasis
Angiogenesis
Composition of microbial species that coexist in complex, multispecies communities
Gut Microbiome
Name of institution that reviews and approves protocols for animal experimentation
IACUC (Institutional Animal Care and Use Committees)
Three locations where immune proteins can be found
Intracellular (inside cell)
Surface of cell
Extracellular (outside cell)
Three most common sites of metastasis
Bone, Liver, Lung
Condition when body or region of body is deprived of adequate oxygen supply
Hypoxia
List three components of the gut microbiome
Bacteria, Fungi, Viruses, Archaea, or Protozoa
3 R's for animal research
Replacement, Reduction, Refinement
Recruits other cells to help with immune response
MHC Class II
Invasion of nearby normal tissue, lymph nodes or blood vessels, and surrounding tissue
Cell adhesion (deadhesion)
Promotes and acts as primary mediator of angiogenesis
VEGF (Vascular Endothelial Growth Factor)
Easiest way to test the gut microbiome
Collect Fecal Sample
Transplantation of cells from one member of a species to another member of the same species
Allotransplantation
Monitoring process of immune system to find and kill abnormal cells
Immune Surveillance
Organ Selectivity Theory has metastatic preference for ease of travel
Mechanistic Theory
Lack of hierarchy, chaotic flow patterns, decreased perfusion
Tumor Blood Vessels
Type of tumor cell that is faster growing, immature, and undifferentiated
Acute Tumor Cell
Transplantation of cells from one species into another species
Xenotransplantation