Hemophilia
This clotting factor is deficient in Hemophilia A.
Factor VIII
This condition present with prolonged PT & PTT, low platelet count, low fibinogen, and elevated D-dimer.
DIC
This disorder involves abnormal function of fibrinogen despite normal levels.
Dysfibrinogenemia
This substance activates plasminogen in the body.
tPA
This protein binds and stabilizes Factor VIII in circulation.
Willebrand factor
This lab result is prolonged in all types of hemophilia.
PTT
This condition afects both coagulation proteins and platelets due to impaired synthesis and splenic squestering.
Liver Disease
This disorder results in complete absence of fibrin formation.
Afibrinogenemia
This enzyme breaks down fibrin clots.
Plasmin
This is the end product of the coagulation cascade.
Fibrin
This inheritance pattern explains most cases of Hemophilia A and B
X-linked recessive
This factor is affected earliest in Vitamin K deficiency due to shortest half-life.
Factor VII
This disorder produces unstable cots despite normal PT and PTT.
Factor XIII
This molecule is produced from the breakdown of cross-linked fibrin.
D-dimer
This enzyme directly converts fibrinogen into fibrin.
Thrombin
Hemophilia B is also called this.
Christmas Disease
These four factors will be decreased in Patients with vitamin K deficiency.
Factors II, VII, IX, & X
In this condition, protein C's ability to break down factor V is impeded, leading to hypercoagulability.
Factor V Leiden
Elevated levels of these indicate increased fibrin or fibrinogen breakdown.
FSPs (FDPs)
These two plasma proteins are synthesized by endothelial cells.
Factor VIII & vWF
This severity level is defined by 1-5% factor activity.
Moderate hemophilia
In this condition plasmin is activated by sources other than thrombin, leading to prolonged PT and PTT, decreased fibrinogen, and increased D-dimer, while platelet count remains normal.
Primary fibrinolysis
This factor deficiency prolongs PTT but is not associated with clinical bleeding.
Factor XII
This inhibitor suppresses the function of TPA.
PAI-1 (Plasminogen activator 1)
This describes thrombin’s anticoagulant role.
Activation of protein C