cell division
The majority of a cell's life is spent in what phase?
interphase
What does it mean for chromosomes to be homologous?
chromosomes are the same length and have genes in the same locations
Tumors form because cancer cells have no _______ inhibition.
contact inhibition
Cyclin binds with Cdk to form a cyclin-Cdk complex. What level of protein structure is this?
quaternary
Which of the following is not a case of transmissible cancer?
a. Tasmanian Devils
b. Canines
c. soft shell clams
d. humans
humans
Mitotic spindles arise from which cell structure?
a. centrosome
b. centromere
c. centriole
d. kinetochore
centrosome
How many origins of replications do prokaryotes have? Compared to prokaryotes, how many do eukaryotes have?
1; more
True/False: Cancer is the result of a the cell cycle being out of control.
true
What is the main prerequisite for clearance at the G2 checkpoint?
a. cell has reached a sufficient size
b. an adequate stockpile of nucleotides
c. accurate and complete DNA replication
d. proper attachment of mitotic spindle fibers to kinetochores
accurate and complete DNA replication
What two stages of the cell cycle often overlap?
telophase and cytokinesis
Which eukaryotic cell cycle event is missing in binary fission?
a. cell growth
b. DNA replication
c. mitosis
d. cytokinesis
mitosis
What is Chargaff's Rule?
complementary base pairing: A --> T, C --> G
What is the multiple hits model?
A cell us being held in G1 phase due to DNA damage. When DNA is damaged, p53 is phosphorylated and prevents entry into what phase?
S phase
What is the difference between positive and negative regulation?
Positive regulation promotes the cell cycle. Negative regulation inhibits the cell cycle.
Identical copies of chromatin held together by cohesin at the centromere are called...
a. histones
b. nucelosomes
c. chromatin
d. sister chromatids
sister chromatids
DNA can only be synthesized in the ______ direction.
5' ---> 3'
If left unchecked, uncontrolled cell division can lead to tumor formation and _______, the growth of cancer cells in new locations in the body.
metastasis
Which protein is positive regulator that phosphorylates other proteins when activated?
a. p53
b. p27
c. Rb
d. Cdk
Cdk (cyclin dependent kinase)
DAILY DOUBLE
Purines have____ rings and include the bases ____ and ______. Pyrimidines have ____ rings and include the bases ______ and _____.
two, adenine, guanine; one, cytosine, thymine, uracil
The first level of DNA organization in a eukaryotic cell is maintained by which of the following?
a. cohesin
b. condensin
c. chromatin
d. histones
histones
True/False: Everything about DNA replication, down to the process and enzymes used, is the same for both prokaryotes and eukaryotes.
false!
Define the term tumor angiogenesis.
Tumors can form new blood vessels for bringing nutrients and oxygen to the tumor.
Which negative regulatory molecule can trigger cell suicide (apoptosis) if vital cell cycle events do not occur?
a. Cdk
b. Rb
c. p21
d. p53
p53 ("the guardian of the genome")
FINAL JEOPARDY
[Talk to your team about how many points you would like to bid]
What is a karyotype?
the number and appearance of chromosomes that includes their length, banding pattern, and centromere position