PK & ADME
PK describes what the body does to the drug. PK describes what the drug does to the __.
Body
DPIs require no actuation-inhalation coordination because they are __-activated
Breath-activated
Reducing particle size is called
Comminution
A filler/diluent increases tablet __
Bulk
Hard gelatin capsules use a plasticizer:gelatin ratio of
0.4:1
A drug with pKa=3.4 in the stomach pH 1.4 is mostly __
Unionized (HA)
Deep lung deposition requires particle size ~ __ um
1-5 um
Mixing equal volumes of a drug and diluent repeatedly is __ __
Geometric dilution
Magnesium stearate is primarily a __
Lubricant
What is the main plasticizer for __ capsules
Hard gelatin
Steady state is reached when drug input equals drug __
Elimination
About __% of aerosole propellants are compressed gases
10%
Granules flow __ than powders
Better
A tablet that releases drug in the intestine is __-coated
Enteric
Capsule size 000 is __ than size 5
Bigger/Larger
Fick's Law: Diffusion rate is NOT directly proportional to __
Membrane thickness
Large fast-moving particles deposit by __ impaction
Inertial
Effervescent granules contain an acid and a __ (give an example too)
Base (Ex: sodium bicarbonate)
A tablet defect where the top separates
Capping
Capsule cGMP includes weight, uniformity, disintegration, dissolution, stability, and __?
Moisture permeation
A drug with Cl = 7 L/hr and Vd = 70 L has a half-life closest to __ hours
6.9 hours
The 4 components of a pMDI: Container, propellant, __/__, and drug
Valve/actuator
Slugging pressures are typically __-__ lbs
8,000-12,000 lbs
About __% of dosage forms are solid oral, and __% are tablets
About 90% of dosage forms are solid oral, and 45% are tablets
Two non-gelatin capsule materials
HPMC & Pulluan