Dapa CKD I
Team Member I
Breztri
Team Member II
Dapa-CKD II
100
An eGFR >= 25 and <= 75 ml/min2

and UACR >= 200 and <= 5000 mg/g at visit one

What is inclusion criteria for patient's to enroll in Dapa-CKD?

100

This PSS is a former policeman, expert marksman, knowledgeable about firearms, and makes pottery too! He attended Auburn University. 

Who is Mike Sharp?

100

74%

How many patients in the KRONOS study did not have an exacerbation in the preceeding 12 months?

100

This PSS is Mom to a college age daughter who attends MS State.  She grew up in Hattiesburg and attended USM. 

Who is Nicole Holmes?

100

19%

What was the number needed to treat to prevent one primary outcome event? 

200

Sustained decline in eGFR of at least 50%

Death from renal or cardiac causes

End Stage Kidney Disease 

What is the composite primary outcome?

200

This PSS grew up in Pennsylvania and attended Shipenberg's University of Pennsylvania.  She is Mom to a girl and two boys and they like vacationing at the Jersey shore. 

Who is Kelly Galiano? 

200

71.8%

What % of patients in KRONOS were on an ICS at screening? 

200

This PSS is from the Jackson, MS, area and attended Ole Miss.  She is Mommy to a little girl and a little boy who love Mardi Gras.  She lives in Uptown NOLA. 

Who is Lauren Williamson?

200

97%

What % of patients were on Standard of Care - ACEI or ARB? 

300

39% RRR

What was the overall RRR for the primary composite endpoint? 

300

This PSS hails from Minden, LA, and attended LA Tech. She is Mama to a little boy and a little girl.  She lives in Lakeview.

Who is Georgia Boswell? 

300

History of hospitalization(s) for COPD exacerbations

>= 2 moderate exacerbations of COPD per year

Blood eosinophils >= 300 cells

History of concomitant asthma

When does the GOLD Guidelines strongly favor initiating ICS treatment? 

300

This team member has traveled Europe with his wife, Petra, who grew up in Slovakia.  He is Daddy to two girls and a boy.  He plays a mean game of Pickleball!

Who is Stephen Hickman?

300

68% and 32% 

What % of patients had T2D and what % did not?

400

36% and 50% RRR

What was the composite endpoint for T2D's and those without T2D?

400

This PSS was a cheerleader, taught Cheer, and owned a Cheer School.  She is Momma to her daughter, a cheerleader, and two sons. 

Who is Angela Blackstock? 

400

1.8%

What is the Ethos overall mortality rate? 

400

This PSS attended LSU and grew up in Nola, but now resides in Covington. She is Mom to two daughters.

Who is Susan Carter?

400

The risk of death from CV causes or HHF was significantly lower in the DAPA group compared to placebo? 

What if the secondary end point in the DAPA-CKD trail?

500

31% RRR

What is the highly significant reduction in all cause mortality? 

500

This PSS was on the Sail Team at the College of Charleston and met her husband thru sailing.  She comes from Rhode Island. She is Mom to three girls.  

Who is Roseanne Eagan? 

500

46%

What was the risk of death that was lower for  budesonide triple therapy vs. glycopyrrolate-formoterol? 

500

This Team Member resides in Kentucky and likes to vacation in Maui, Hawaii.

Who is Katie Dingle? 

500

43 ml/min2 

What is the mean eGRF at baseline for patients in the DAPA group?