GLP1 Disease State
What are the 2 Incretin Hormones?
GLP1 and GIP
True or False
No dose adjustment of Ozempic is recommended for patients with renal and hepatic impairment
True
I love camping and the great outdoors!
Greg
*High Efficacy
*Low risk of hypoglycemia
*Weight Loss
*GI side effects are common (nausea and vomiting)
*No generic available
Which organ does GLP1 help suppress appetite resulting in decreased energy intake and subsequent weight loss?
Brain
Which organ does GLP1 effect as far as indirectly inhibiting Glucagon secretion, causing a reduced hepatic glucose production?
Liver
My favorite band is Pink Floyd
MIKE
Which organ does GLP1 stimulate insulin secretion and indirectly inhibit glucagon secretion in a glucose dependent manner?
Pancreas
I was born in Santa Fe, New Mexico
REBECCA
___ occurs when insulin cannot effectively act on its target tissues to help the transport of glucose into the cells?
Insulin Resistance
Name 2 out of 3 Microvascular Complications
Retinopathy, Nephropathy, Neuropathy
I was an Extra in the movie, The Replacements with Keanu Reeves and Gene Hackman
LARRY
Name 2 out of 4 Macrovascular complications
Stroke, Coronary Artery Disease, Heart Failure, Peripheral Artery Disease
When I was a baby, my mom entered me in a Huggies baby crawling competition and I won 1st place. The prize was free diapers for a year!
RYAN
Semaglutide is a GLP1 analogue with _____ sequence homology to human GLP1.
Semaglutide is a GLP1 analogue with 94% sequence homology to human GLP1.
What 2 core defects are NOT addressed by GLP1?
Adipose Tissue
Kidneys
This is a trail that I hike.
How long is the trail & when was it established
MARK
60 miles & year built 1832
What are Warnings and Precautions of Ozempic?
*Pancreatitis
*Diabetic Retinopathy Complications
*Never share an Ozempic pen between patients, even if the needle is changed
*Hypoglycemia
*Acute Kidney Injury
*Adverse Gastrointestinal Reactions
*Hypersensitivity Reactions
I do lunges as I’m brushing my teeth. It always seemed like such a long time wasted staring at myself in the mirror. Now my child thinks that’s how you brush your teeth!
TERRI
What is the incretin effect?
The INCRETIN Effect is the difference in insulin secretion following oral glucose intake compared with that observed after an IV glucose infusion
What is the mechanism of action of GLP1?
*Bind to GLP1 receptors on pancreatic beta cells and stimulate glucose-dependent insulin secretion
*Glucagon suppression: glucose-dependent suppression of glucagon production causes reduced glucose production by the liver
*Slowed gastric motility: slows stomach emptying, which reduces the rate of glucose absorption from the intestine
Name 3 of the 8 core defects in the Ominous Octet?
Gut, Pancreas, Liver, Muscle, Brain, Adipose Tissue, Kidneys
I visited one of the oldest churches in the world
MARK
The church was in Bellagio Como Italy