Cell Cycle
The "maturation promoting factors" that drive frog oocytes (any cell, really) through cell cycle phases
What are CDKs?
Some bacterial toxins or burns from your stove might lead to this kind of death for skin cells
What is necrosis?
An actin nucleation promoting factor that 'stings'
What is WASP?
"Under Pressure" (tension, to be precise) is key for this cell cycle checkpoint
What is spindle assembly (or M phase) checkpoint?
Intermediate filaments degraded during division and death
What are lamins?
Inhibitor of G1/S cylin-CDK complex following DNA damage
What is p21?
A critical actin-dependent step in apoptosis that prevents inflammation
What is phagocytosis?
Equivalent filament growth and shrinkage at the plus and minus ends respectively
What is treadmilling?
"Life Is A Highway" is true of these MAPs heading to the MTOC
What are dyneins?
Immunofluorescence against this phosphorylated protein may tell you if the cell just passed the cell cycle 'point of no return'
What is Rb?
In microcephaly, the absence of this functional microtubule-associated protein causes failure of mitotic spindle formation and cytokinesis
What is ASPM?
I go from powering the cell to powering its demise upon my release
What is cytochrome c?
A feature of microtubules that prevents immediate depolymerization during growth
What is the GTP cap?
"Stayin' Alive" is the perfect theme song for some members of this protein family
What is Bcl-2?
A transcriptional activator for mediators of apoptosis and cell cycle arrest
What is p53 (tumor suppressor gene)?
(Activates P21, NOXA, PUMA)
What is securin?
The executioner caspase cleaves these targets, leading to bleb formation
What are cytoskeletal filaments?
Cells move and eat, mostly because of this 'array'
What is actin cross-linked gel?
In droplet based scRNA-seq the cell is "Happy Together", assuming its with this
What is a barcoded gel bead?
A newly discovered cell type that makes bowels quake in response to the pathogen Vibrio cholerae
What are BEST4 cells?
Cancer cells already live dangerously. Blocking this inhibitory kinase removes the brakes on M-CDK, pushing them into mitotic catastrophe
What is Wee1?
You run an agarose gel to detect the death-inducing effects of this enzyme
What is CAD (Caspase-Activated DNase)?
Actin- and tubulin-based filaments need me, but intermediate filaments do not
What is energy?
(or energy-carrying nucleotides)
"Another One Bites the Dust" when this zymogen is autoactivated.
What is Procaspase 8?
(part of the Death-Inducing Signal Complex)
There are old pickers and bold pickers, but no old bold pickers. What might the bold pick if they want to label actin?
What is Amanita phalloides (‘Angel of death’ mushroom)?