Immunopathology 1
Immunopathology 2
Pathophysiology Flashback
Leukocytes and cytokines
100
A disease caused by insulin resistance and insufficient insulin production by the endocrine pancreas.
Diabetes Mellitus II. Amyloidosis of the Islets of Langerhans is seen on imaging.
100
The dark zone surrounding a germinal center.
Mantle (or marginal zone)
200
A disorder characterized by the destruction of exocrine glands, including salivary and lacrimal glands.
Sjogren's Syndrome. Diagnostic with SSA/Ro and SSB/La antigens in the blood and associated symptoms.
200
A disease characterized by mutation in BTK that results in low levels of immunoglobulins.
Agammaglobulinemia (Burton's Disease)
200
A disorder caused by destruction of the adrenal gland, mostly by autoimmune disease. The result is fatigue, weakness, weight loss, bronze skin, and potential shock.
Primary adrenal insufficiency (Addison's disease)
200
The circular portion of DNA created as a by-product of VDJ recombination that may also be used as a screening tool for immunodeficiency.
KRECs (BRECs) and TRECs
300
A disorder caused by mutations in adhesion proteins, such as selectin or integrin, that results in leukocyte recruitment dysfunction.
Leukocyte adhesion deficiencies (LADs).
300
A disease of unknown etiology that results in noncaseating (non-necrotizing) granulomas on histopathology. The disease commonly affects the lungs and skin.
Sarcoidosis. Treatment is corticosteroids or other immune modulators.
400
A disease caused by mutation in NADPH oxidase that results in dysfunction of phagocytic activity.
Chronic granulomatous disease (CGD). Treatment is bone marrow transplant.
500
A disease caused by mutation in phosphatidylinositol glycan A (PIGA) that results in the destruction of red blood cells by complement activation.
Paroxysmal nocturnal hemoglobinuria (PNH). The cure for which is eculizumab or marrow transplant. Deficiency in PIGA causes RBC Decay accelerating factor (complement inhibitor) dysfunction.
500
Five congenital heart defects that cause a right to left shunt resulting in cyanosis of the newborn.
Patent truncus arteriosus, transposition of the great arteries, tricuspid atresia, tetralogy of Fallot, total anomalous pulmonary venous return.