Gas Laws
Respiratory Anatomy
Gas Transport
Hb-O2 Dissociation Curve
Mechanism of Bohr Shift
100

This law states that gases diffuse from a high to low pressure until equilibrium has been reached

Henry's Law

100

The part of the throat in the posterior of the mouth is called the ____________________.

Nasopharynx

100

Oxygen is transported through the blood is two ways. List the two ways and the percentage of O2 transported in each way.

98.5% of O2 travels attached to hemoglobin

1.5% of O2 is dissolves in the plasma

100

Where is the body would we find Hb 100% saturated with O2?

at the lungs

100

What process generates CO2 and H2O in the tissues?

Aerobic metabolism

200

This gas law states that as temperature increases, volume of a gas also increases

Charles' Law

200

This is the anatomical term for "voice box"

larynx

200

Carbon Dioxide is transported through the blood in three ways. List the three ways and the percentage of CO2 transported in each way.

1. As bicarbonate ions (HCO3-): 70%

2. As carbaminohemoglobin: 23%

3. Dissolved in plasma: 7%

200

At resting tissues, PO2 = ______mmHg. This coincides with dissociation of one O2. 

40 mmHg

200

When CO2 and H2O enter a RBC, this enzyme converts then to H2CO3.

Write out the name of H2CO3: _________ ___________.

Carbonic Anhydrase

H2CO3: carbonic acid

300

This law states that the total pressure of a mix of gases equals the sum of the partial pressures of all the gases in the mix

Dalton's Law

300

This is the flap of cartilage which closes over the trachea when a person is swallowing

Epiglottis

300

How many O2 molecules can 1 hemoglobin (Hb) bind at a time?

If Hb is currently 25% saturated with O2, how many O2 molecules is each Hb holding? 

4 O2

1 O2

300

Though the Hb-O2 dissociation curve is flat where PO2 is high, why does Hb's affinity for O2 drop steeply between 40mmhg to 20mmHg?

Exercising (more active) tissues need more oxygen quickly

300

When H2CO3 is produced in the RBC, it immediately dissociates into ____________ and ____________.


HCO3- (bicarbonate)


H+

400

According to Boyle's Law, as the volume of a container increases, the gas pressure in the container ______________________.

decreases

400

When the trachea splits into left and right "tubes", these tubes are called ___________  ____________.

primary bronchi

400

Define the word affinity as it applies to Hb's affinity for O2. How does this affect Hb's saturation with O2.

Affinity means how strongly/readily Hb will bind to O2.

A high Hb-O2 affinity = high percentage Hb-O2 saturation.

A low Hb-O2 affinity = low percentage Hb-O2 saturation.

400

Hb saturation with O2 rarely drops below 25% in the venous reserve, even if a tissue is in great need of O2.

What other mechanism compensates to bring more O2 to the tissues that need maximum O2?

vasodilation to those tissues (increase in perfusion)

400

In the RBC, H+ ions will bind to ___________. This is called allosteric binding since. 

_____________ also binds to Hb allosterically.

In both cases, this causes Hb's affinity to ___________ (decrease/increase).

Hb

CO2 (forming carbamino-Hb)

decrease

500

This gas law explains the concept of Negative Pressure Ventilation

Boyle's Law

500

These are the structures, covered in pulmonary capillaries, where gas exchange with the blood takes place.

Alveoli

500

Which two vessels are carrying the highest PO2?

a. Pulmonary arteries

b. Pulmonary veins

c. Systemic arteries

d. Systemic veins

b. pulmonary veins

c. systemic arteries

500

A Bohr shift, such as that caused by a lower tissue pH, causes the "position of the Hb-O2 sigmoid curve" to shift to the __________ (right/left). 

What this really means, is that at a given tissue PO2, Hb will release _________ (more/less) O2 due to the drop in pH.

right

more

500

When HCO3- (bicarbonate ions) are produced in the RBC, they cannot stay in the ICF permanently. HCO3- ions pushed out of the ICF and _______ions are brought into the ICF to maintain electrical balance.

This is known as the __________  ___________.

chloride (Cl-)

Chloride Shift