Indications for T Replacement
Workup snd Monitoring for Low T
Evidence of Efficacy of T Replacement
Anabolic Steroids
Other Prefomance Enhancing Drugs
100
These include reduced sexual desire and activity, decreased AM erections, ED, hot flushes, decreased body hair and gynecomastia.
What are specific signs and symptoms of agre related hypogonadism.
100
These include testosterone level, LH/FSH, HgB and PSA.
What are labs that should be drawn in initial evaluation of possible low T?
100
These include modest increase in sexual activity, sexual desire and less ED, but only in hypogonadal males.
What is do studies show improvement in sexual function?
100
Between 3 and 6%.
What is the percentage of 16 year old males who report having ever used anabolic steroids?
100
Studies have shown these often do not contain the active ingredient listed or may contain actual anabolic steroids?
What are oral steroid precursors such as DHEA?
200
These include obesity, the metabolic syndrom, T2DM, ESRD and end stage COPD.
What are conditions often associated with reduced testosterone production?
200
Always before 11:00 AM.
What is when should T levels be drawn?
200
Men on treament with T had no significant increase in 6 minute walking distance compared to placebo. A combination of several trials did show an improvement.
What is what is the evidence for improvement in physical function in men on testosterone replacement?
200
These include belief that steroids improve athletic performance, less concern over adverse effects, less satisfaction with thier physiques, impulsivity, hostiltiy and a tolerance of drug use by friends.
What are corelates of snabolic steroid use?
200
This has been shown to increase VO2 max, it';s less clear it improves actual athletic performance.
What is EPO?
300
These include three sexual symptoms (decreased sexual thoughts, weakened or less frequent morning erections and ED) and either a total T<230 or a T<217 with a free T level < 63.
What do published quidelines suggest as the most predictive criteria for low T?
300
These include metastatic prostate Ca, breast Ca, elevated PSA, polycytemia, severe BPH, stage 4 CHF, severe OSA and male infertility.
What are contraindications for testosterone replacement?
300
A large meta analysis showed no improvement in this after a year of testosterone replacement.
What is physical strength?
300
This was only shown for subjects with training, dietary control and high intensity training.
What is when does anabolic steroid use lead to increases in strength?
300
This works less from direct effect and more through induction of IGLF release.
What is rhGH?
400
These include decrease in lean body mass, increase in visceral obesity, decreased energy levels, mood changes, and decreased cognitive function.
What are nonspecific symptoms of age related hypogonadism?
400
Taget should be midpont of the "normal agre adjusted" level.
What is the level of T that should be aimed for with replacement?
400
T replacement showed no effect on this symptom measured in a scale called FACIT.
What is fatigue?
400
No trails have shown an improvement in this from anabolic steroid use.
What is aerobic performance?
400
There are no controlled studies studying the effects of this in adolescents.
What is rh GH?
500
These include steroids, opioids, MJ and EtOH.
What are substances that can reduce testosterone production?
500
These include T levels, H/H, PSA, DRE and possibly BMD.
What are labs and exam elements that should be done for monitoring on T replacement?
500
One RCT did show an increased risk of this, but multiple other observation studies and meta-analysis have coem to differing conclusions (some yes and some no).
What is, is there cardiovascular risk from testosterone replacement?
500
These include decrease in testicular size, acne, gynecomastia, liver toxicity, emotional changes and premature epiphyseal closure.
What are potential side effects of anabolic steroid use?
500
Often used by body builders shortly before judging.
What are diuretics?