Stem cell Transplant
Process of creating new blood cells from stem cell
What is hematopoiesis?
Mature in the bone marrow. Responsible for antibody-mediated immunity.
What are B lymphocytes (B-cells)?
Part of Innate immunity. The cell responsible for first-line response against infection, especially bacteria.
What is a neutrophil?
Total neutrophil % x WBCs =
What is Absolute neutrophil count?
4 types of T-lymphocytes
What are Helper T-cells, Cytotoxic T-cells, Memory T-cells and Suppressor T-cells?
The ability to develop into many different types of cells or tissues in the body
What is pluripotent?
Produced in the bone marrow. Migrate to the thymus where they mature and develop the ability to recognize antigens.
What are T-lymphocytes or T-cells?
Cells that are responsible for allergic responses.
What are eosinophils?
(Polys/Segs + Bands)/100 =
What is total neutrophil %?
Able to replicate VERY fast and initiate a response very fast if they have encountered an antigen before
What are Memory T-cells
Hematopoietic stem cells produce these 2 progenitors
What are Myeloid and Lymphoid progenitors?
Assist T-cell and B-cell activation when presented with antigens.
What are Dendritic cells?
Cells that respond to parasitic infections.
What are basophils?
Immature, but functioning neutrophils that are released with injury or inflammation in the body
What are Bands?
Bind to B-lymphocytes (B-cells) which causes release of lymphokines
What are Helper T-cells (CD4)?
Lymphoid progenitors develop into these
T-lymphocytes and B-lymphocytes
Differentiate into plasma cells which release antibodies specifically against the antigen it is bound to.
What are B-cells?
Monocytes migrate out of bone marrow into the peripheral circulation, enter tissue and mature into this.
What are macrophages?
The most numerous type of WBCs. The first line of defense against invading organisms.
What are Segs or segmented neutrophils, polys of PMNs)?
Inhibit the immune response so it stops when the infection has been controlled.
What are Supressor T-cells?
Myeloid progenitors develop into these.
Red Blood cells, Platelets, Neutrophils and Macrophages.
An undifferentiated cell that can give rise to different cells, tissues and organs.
What is a stem cell?
3 sources of stem cells
Bone marrow, umbilical cord blood, peripheral blood
Spongy porous material in the center of most bones where hematopoiesis occurs
Bone Marrow.
Especially in vertebrae, ribs, sternum and long bones
90% hematopoietic stem cells are present in bone marrow at birth. 50% present by 30yo. 30% by 70yo.
Bind to MHC1, major histocompatibility complex class 1, molecules on the cell surface which display intracellular proteins and initiate apoptosis via cytotoxins if the cell has been infected by a virus.
What are Cytotoxic T-cells or CTLs (CD8)?