What is Keratin 5 and 14. 3 forms of EBS: Dowling Meara, Koebner, Weber Cockayne
100
What is the normal transit time for the keratinocyte to reach the stratum corneum and to desquamate?
What is 14 days and 14 days: total 28 days
100
What is the reliable marker/stain for Merkel cell?
ck20: keratin 20. perinuclear dot pattern
also: neuron specific enolase, and CAM 5.2
100
Name the layers of the hair follicle from outer to inner?
What is outer root sheath, inner root sheath: henle's layer, huxleys layer, cuticle. Shaft: cuticle, cortex, and medulla
100
Triangle shaped hair?
What is Uncombable hair syndrome
200
What are the keratins expressed in the suprabasal layer?
What is Keratin 1 and 10. keratin 1 defect: Ichythosis hystrix of Curth-Macklin and Diffuse non-epidermolytic PPK ( Unna-Thost). 1, and 10: EHK
200
Name name 2 of the 3 disorders associated with a connexin 26 defect?
What is Vohwinkels syndrome, KID syndrome, PPK and deafness (GJB2).
30.3 and 31: erythrokeratodermia variabilis (GJB3-4)
30 hidrotic ectodermal dysplasia (GJB6)
200
What is the epidermal melanin unit in the epidermis?
What is 36k:1melanocyte
- Hair: 5k:1 melanocyte
200
What percentage of hairs are in anagen?
What is 84%
telogen: 14%
catagen: 2%
200
These allow the rapid shunting of blood from the arterioles to venules, bypassing capillaries?
What is Susque-Hoyer canals seen in glomus tumor and glomangioma.
300
What are the keratins for PC-1 and 2
What is PC-1: 6a, 16. PC-2 6b and 17. Steatocystoma multiplex is K17
300
Name the keratins produced in the granular layer?
What are K2,11
- basal layer: K5,14
- spinous layer: K1,10
300
Name 2 stains used to detect Langerhans cells?
What CD1a, s100, ATPase(1st marker), CD45, actin, vimentin.
kidney shape nucleus on H&E, birbeck granules on EM.
300
What is the form of secretion of sebaceous glands?
What is Holocrine.
- eccrine: paracrine
-apocrine: decapitation secretion
300
Which gene mutation accounts for red hair?
What is MC1-R
400
What keratins are considered hyperproliferative and often seen in psoriasis?
What is K6a and 16
400
What is another name for the lamellar granules?
What is Odland bodies
Disease related disorders
a) Flegel's disease: decreased lamellar granules
b) Harlequin ichthyosis: abnormal or absent: ABCA12 can be seen in lamellar ichthyosis
c) x-link ichyosis: steroid sulfatase missing in lamellar granules
400
Name 2 disorders associated with the C-kit mutation?
What is mastocytosis and piebaldism.
-also melanoma
400
What is the growth of hair per day?
What is 0.4mm/day
400
What is the kd for the dysfunctional desmosomal protein (desmoplakin) seen in Carvajal syndrome
What is type I 250, II-210
500
Acidic and Basic keratins are co-expressed in order to form these filamentous structures?
What are obligate heteropolymers
500
Which component of the cornified cell envelope is elevated in psoriasis?
What is Involucrin.
- loricrin and filaggrin are decreased
- loricrin makes up 75-80% of CE
500
Which of the following is NOT a preformed mediator?
a) Tryptase
b) Chymase
c) Neutrophil chemotactic factor
d) Platelet activating factor
e) Eosinophilic chemotactic factor
What is D
500
What is responsible for the odor in apocrine glands?
What is C6-C11 acids- the most abundant is 3 methyl-2-hexanoic acid.
- pigmented sweat: lipofuscin
500
Which collagen type accounts for 10% of collagen?
What is Collagen type III,
- type I: 85%
- type V: 5%