Gen-pardy

Experiments

100

What did the baby hamster kidney experiment show for mutants I, II, and IV?

Lack of cAMP production due to loss of ADCY3 catalytic function.

200

What is the function of forskolin?

Stimulates adenylate cyclases.

Experiments 2

100

What does WES stand for?

Whole Exome Sequencing.

200

Why were only two mutant proteins modeled? 

Structural data for important domains was only available for ADCY3 Mut-I and Mut-II

ADCY3

100

What does ADCY3 do to ATP?

ADCY3 catalyzes ATP into cAMP and pyrophosphate.

200

What symptoms did mice with their ADCY3 gene knocked out show?

Hyperplasia (over-eating), anosmia (lack of smell)

ADCY3 2

100

Which type of mutation inheritance is responsible for affecting the functionality of ADCY3?

Two copies of the recessive allele

200

Was there stabilization or destabilization in the mutADCY3 catalytic domains during the stimulations?

destabilization