Show:
Cytogenetics
Histology
Partial vs complete mole
Treatment of malignant sequelae
Big Picture
100
Complete mole karyotype
What is 46 XX
100
80% of GTD
What is hydatidiform mole
100
Percent neoplastic sequelae for partial vs complete mole?
What is 4 vs. 20%
100
Most common regimen for low risk disease
What is methotrexate 50 mg/m2
100
All types of GTN (4)
What is invasive hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Epithelioid trophoblastic tumor
200
Partial mole karyotype
What is 69 XXY
200
After evacuation of molar pregnancy, trophoblastic tissue persists in ____ % patients overall
What is 20%
200
Presence of this distinguishes the two
What is presence of fetal tissue
200
Multi-drug regimen for high-risk disease
What is EMA-CO
200
Lesions arise from ___ not ___ tissue
What is lesions fetal not maternal tissue?
300
Autosomal recessive condition predisposing to molar pregnancy
What is mutation on chromosome 19 leading to underexpression of p57(KIP2)
300
The risk of _______ is increased after a complete mole and has only rarely been reported after a partial mole
What is risk of choriocarcinoma?
300
I am more common numbers wise!
What is partial mole
300
Birth control method preferred during treatment and observation
What is OCPs
300
Persistent elevation of serum hCG following any nonmolar pregnancy, eg, miscarriage, ectopic, or preterm/term pregnancy, is more commonly due to ____
What is choriocarcinoma
400
Downregulation of _____ tumor suppressor genes has been demonstrated in GTD
p53, p21, Rb
400
Choriocarcinoma consists of this
What is anaplastic cytotrophoblasts and syncytiotrophoblasts without chorionic villi
400
large for dates vs small for dates
What is uterine size
400
WHO score cut off for low risk disease
What is 6
400
Three types of hydatidiform mole
What is complete hydatidiform mole Partial hydatidiform mole Invasive mole (chorioadenoma destruens)
500
Cell types present in complete mole
What is chorionic villi and atypical trophoblasts
500
Rarest form of GTN
What is epithelioid trophoblastic tumor
500
___ mole is more associated with choriocarcinoma
What is complete mole
500
Procedure accepted as initial treatment in women over 40
What is hysterectomy
500
Two blood hormones identifying most of GTN
What is BHCG and hPL