Drugs
Name all 3 beta-lactamase inhibitors of the penicillin class that treat anaerobes?
Piperacllin/Tazobactam, Amoxicillin/clavulanic acid, Ampicillin/Sulbactam
How to the beta lactamase inhibitors of anaerobes stop the bacteria?
Inhibit cell wall synthesis via peptidoglycan binding/inhibition
Common site of infection of anaerobe, 3 answers
Intra-abdominal, CNS, the oral cavity and skin
The only macrolide that covers Atypicals
Azithromycin
What kind of cell wall to Atypicals have?
Modified/absent
What group of antibiotics that are knonw as beta lactams treat anaerobes?
Carbapenems
Carbapenem has a mechanism of action that does what ?
Inhibits cell wall synthesis. That is why they are Beta lactams
<20%
The only tetracycline that treats Atypicals
Doxycycline
What are most atypical infections the cause of ?
Hint: Think Location
Respiratory infection
This odd antibiotic known as a nitroimidazole also treats anaerobes as its only use, what is it ?
metronidazole
Bonus *What is the MOA for Metronidazole?
Breaks DNA strands of bacteria
The 3 gram (+) anaerobic bacteria
Clostridium, Actinomyces, Peptostreptocci
*Anaerobes like to CAP.
This is the only fluoroquinolone that CANT treat Atypicals
Delafloxacin
Which antibiotics MOA will be the least effective against Atypicals ?
Any of the ones that target the cell wall i.e beta lactams, aminoglycoside..vancoymcin, dapotmycin, linezolid
These 2 drugs are from the fluoroquinolone family and are used to treat anaerobes.
Moxifloxacin and Delafloxacin
What is the MOA for the fluoroquinolones that treat anaerobes?
DNA gyrase & topisomerase inhibition
When are anaerobes most clinically significant? 2 answers
Polymicrobial infections & absecesses
T or F, All Beta-Lactams cover Atypicals
False, Penicillins, Carbapenems and Cephalosporins do not cover atypicals
The three species of atypicals for this class are
Mycoplasma, Chlamydia, Legionella
The Two cephalosporin second generations treat anaerobes
Cefotetan & Cefoxitin
Cefotetan and cefoxitin are cephalosporins that treat anaerobes, the MOA is ?
Inhibition of cell wall synthesis via peptidogolycan inhibition
The one gram (-) anaerobe that will be used in class
Bacteroids fragilis
T or F Vancomycin, Linezolid and Daptomycin cover both Atypicals and Aneorobes?
False they do not cover either
The most commonly prescribed atypical antibiotic for inpatient and outpatient that most bacteria have become resistant to
Azithromycin or Zithromax